Phosphoprotein
![](http://upload.wikimedia.org/wikipedia/commons/thumb/c/c5/Phosporylation_of_a_serine_residue%2C_before_and_after_shot.png/220px-Phosporylation_of_a_serine_residue%2C_before_and_after_shot.png)
A phosphoprotein is a protein that is posttranslationally modified by the attachment of either a single phosphate group, or a complex molecule such as 5'-phospho-DNA, through a phosphate group. The target amino acid is most often serine, threonine, or tyrosine residues (mostly in eukaryotes), or aspartic acid or histidine residues (mostly in prokaryotes).[1]
Biological function
[edit]The phosphorylation of proteins is a major regulatory mechanism in cells.[2][3]
Clinical significance
[edit]Phosphoproteins have been proposed as biomarkers for breast cancer.[4][2]
See also
[edit]References
[edit]- ^ Keyword - Phosphoprotein
- ^ a b Phosphoproteins in extracellular vesicles as candidate markers for breast cancer
- ^ Cozzone AJ (1988). "Protein phosphorylation in prokaryotes". Annu. Rev. Microbiol. 42: 97–125. doi:10.1146/annurev.mi.42.100188.000525. PMID 2849375.
- ^ Liquid Biopsy Could Get Boost from Phosphoproteins. 2017