Protein-coding gene in the species Homo sapiens
Protein BTG3 is a protein that in humans is encoded by the BTG3 gene .[ 5] [ 6]
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system .[ 6]
^ a b c ENSG00000154640 GRCh38: Ensembl release 89: ENSG00000281484, ENSG00000154640 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022863 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Yoshida Y, Matsuda S, Ikematsu N, Kawamura-Tsuzuku J, Inazawa J, Umemori H, Yamamoto T (Jun 1998). "ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system" . Oncogene . 16 (20): 2687–93. doi :10.1038/sj.onc.1201805 PMID 9632145 . S2CID 10053424 . ^ a b "Entrez Gene: BTG3 BTG family, member 3" . Matsuda S, Rouault J, Magaud J, Berthet C (2001). "In search of a function for the TIS21/PC3/BTG1/TOB family". FEBS Lett . 497 (2–3): 67–72. doi :10.1016/S0014-5793(01)02436-X . PMID 11377414 . S2CID 43120613 . Guéhenneux F, Duret L, Callanan MB, Bouhas R, Hayette S, Berthet C, Samarut C, Rimokh R, Birot AM (1997). "Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle". Leukemia . 11 (3): 370–5. doi :10.1038/sj.leu.2400599 . PMID 9067576 . S2CID 12912055 . Hattori M, Fujiyama A, Taylor TD, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K (2000). "The DNA sequence of human chromosome 21" . Nature . 405 (6784): 311–9. Bibcode :2000Natur.405..311H . doi :10.1038/35012518 PMID 10830953 . Birot A, Duret L, Bartholin L, Santalucia B, Tigaud I, Magaud JP, Rouault JP (2000). "Identification and molecular analysis of BANP". Gene . 253 (2): 189–96. doi :10.1016/S0378-1119(00)00244-4 . PMID 10940556 . Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex" . Jpn. J. Cancer Res . 92 (6): 592–6. doi :10.1111/j.1349-7006.2001.tb01135.x . PMC 5926753 PMID 11429045 . Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14. doi :10.1016/j.cell.2006.03.032 PMID 16713569 . S2CID 13709685 . Ou YH, Chung PH, Hsu FF, Sun TP, Chang WY, Shieh SY (2007). "The candidate tumor suppressor BTG3 is a transcriptional target of p53 that inhibits E2F1" . EMBO J . 26 (17): 3968–80. doi :10.1038/sj.emboj.7601825 . PMC 1994125 PMID 17690688 .
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