Protein-coding gene in the species Homo sapiens
Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene .[ 5]
RAS (MIM 190020) GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. Guanine-nucleotide exchange factors (GEFs), such as RASGRFs, stimulate the conversion of the GDP-bound form into the active form.[supplied by OMIM][ 5]
Variations in this gene has been shown to be linked to the propensity to binge drink by teenagers.[ 6]
Fam NP, Zhang LJ, Rommens JM, et al. (1997). "Mapping of the Ras-GRF2 gene (GRF2) to mouse chromosome 13C3-D1 and human chromosome 5q13, near the Ras-GAP gene". Genomics . 39 (1): 118–20. doi :10.1006/geno.1996.4484 . PMID 9027497 . Fam NP, Fan WT, Wang Z, et al. (1997). "Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras" . Mol. Cell. Biol . 17 (3): 1396–406. doi :10.1128/mcb.17.3.1396 . PMC 231864 . PMID 9032266 . Fan WT, Koch CA, de Hoog CL, et al. (1998). "The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways" . Curr. Biol . 8 (16): 935–8. Bibcode :1998CBio....8..935F . doi :10.1016/S0960-9822(07)00376-4 . PMID 9707409 . S2CID 8904502 . Anborgh PH, Qian X, Papageorge AG, et al. (1999). "Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf" . Mol. Cell. Biol . 19 (7): 4611–22. doi :10.1128/mcb.19.7.4611 . PMC 84259 . PMID 10373510 . Lutchman M, Kim AC, Cheng L, et al. (2002). "Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways" . Eur. J. Biochem . 269 (2): 638–49. doi :10.1046/j.0014-2956.2001.02694.x . PMID 11856323 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 . Arozarena I, Matallanas D, Berciano MT, et al. (2004). "Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors" (PDF) . Mol. Cell. Biol . 24 (4): 1516–30. doi :10.1128/MCB.24.4.1516-1530.2004 . PMC 344182 . PMID 14749369 . Chen H, Suzuki M, Nakamura Y, et al. (2006). "Aberrant methylation of RASGRF2 and RASSF1A in human non-small cell lung cancer" . Oncol. Rep . 15 (5): 1281–5. doi :10.3892/or.15.5.1281 . PMID 16596198 . Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 . PMID 17353931 . Ruiz S, Santos E, Bustelo XR (2007). "RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses" . Mol. Cell. Biol . 27 (23): 8127–42. doi :10.1128/MCB.00912-07 . PMC 2169177 . PMID 17923690 .