Protein-coding gene in the species Homo sapiens
Regulator of G-protein signaling 16 is a protein that in humans is encoded by the RGS16 gene .[ 5] [ 6]
The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade.[ 6]
RGS16 has been shown to interact with GNAQ [ 7] GNAI3 .[ 8] [ 9]
^ a b c GRCh38: Ensembl release 89: ENSG00000143333 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026475 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Snow BE, Antonio L, Suggs S, Siderovski DP (Jan 1998). "Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene". Gene . 206 (2): 247–53. doi :10.1016/S0378-1119(97)00593-3 . PMID 9469939 . ^ a b "Entrez Gene: RGS16 regulator of G-protein signalling 16" .^ Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM (Dec 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis" . Nature Cell Biology . 5 (12): 1095–103. doi :10.1038/ncb1065 . PMID 14634662 . S2CID 6798899 . ^ Chen C, Zheng B, Han J, Lin SC (Mar 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast" . The Journal of Biological Chemistry . 272 (13): 8679–85. doi :10.1074/jbc.272.13.8679 PMID 9079700 . ^ Beadling C, Druey KM, Richter G, Kehrl JH, Smith KA (Mar 1999). "Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes" . Journal of Immunology . 162 (5): 2677–82. doi :10.4049/jimmunol.162.5.2677 PMID 10072511 . Berman DM, Wilkie TM, Gilman AG (Aug 1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits" . Cell . 86 (3): 445–52. doi :10.1016/S0092-8674(00)80117-8 PMID 8756726 . S2CID 12427406 . De Vries L, Zheng B, Fischer T, Elenko E, Farquhar MG (2000). "The regulator of G protein signaling family". Annual Review of Pharmacology and Toxicology . 40 : 235–71. doi :10.1146/annurev.pharmtox.40.1.235 . PMID 10836135 . Chen CK, Wieland T, Simon MI (Nov 1996). "RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling" . Proceedings of the National Academy of Sciences of the United States of America . 93 (23): 12885–9. Bibcode :1996PNAS...9312885C . doi :10.1073/pnas.93.23.12885 PMC 24015 PMID 8917514 . Chen C, Zheng B, Han J, Lin SC (Mar 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast" . The Journal of Biological Chemistry . 272 (13): 8679–85. doi :10.1074/jbc.272.13.8679 PMID 9079700 . Buckbinder L, Velasco-Miguel S, Chen Y, Xu N, Talbott R, Gelbert L, Gao J, Seizinger BR, Gutkind JS, Kley N (Jul 1997). "The p53 tumor suppressor targets a novel regulator of G protein signaling" . 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"Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of Gi- and Gq-mediated signaling" . The Journal of Biological Chemistry . 274 (26): 18836–42. doi :10.1074/jbc.274.26.18836 PMID 10373502 . Pashkov V, Huang J, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Esser V, Gerard RD, Uyeda K, Towle HC, Wilkie TM (Apr 2011). "Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner" . The Journal of Biological Chemistry . 286 (17): 15116–25. doi :10.1074/jbc.M110.216234 PMC 3083217 PMID 21357625 . Popov S, Yu K, Kozasa T, Wilkie TM (Jul 1997). "The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro" . Proceedings of the National Academy of Sciences of the United States of America . 94 (14): 7216–20. Bibcode :1997PNAS...94.7216P . doi :10.1073/pnas.94.14.7216 PMC 23796 PMID 9207071 . Popov SG, Krishna UM, Falck JR , Wilkie TM (Jun 2000). "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity" . The Journal of Biological Chemistry . 275 (25): 18962–8. doi :10.1074/jbc.M001128200 PMID 10747990 . Zheng B, Chen D, Farquhar MG (Apr 2000). "MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16" . Proceedings of the National Academy of Sciences of the United States of America . 97 (8): 3999–4004. Bibcode :2000PNAS...97.3999Z . doi :10.1073/pnas.97.8.3999 PMC 18131 PMID 10760272 . Chatterjee TK, Fisher RA (Aug 2000). "Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs" . 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