RNR5

RNR5
Identifiers
Aliases	RNR5, RNA, ribosomal 45S cluster 5
External IDs	OMIM: 180454; GeneCards: RNR5; OMA:RNR5 - orthologs
Orthologs
	6056
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	Wikidata
View/Edit Human

RNR5 (RNA, ribosomal 45S cluster 5^[2]) is a human ribosomal DNA gene located on Chromosome 22. Tandem copies of this gene form one of five nucleolus organizer regions in the human genome, they are located on the chromosomes 13 (RNR1), 14 (RNR2), 15 (RNR3), 21 (RNR4), 22 (RNR5).^[3]^[2] Each gene cluster contains 30–40 copies and encodes a 45S RNA product that is then cleaved to form 18S, 5.8S and 28S rRNA subunits. In general, genes for RNA remain poorly annotated in most large public databases.

References

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: RNR1 RNA, ribosomal 5". Retrieved 2024-08-01.
^ Schmidt, Olaf (2017). Fritsche, Olaf (ed.). Genetik und Molekularbiologie [Genetics and molecular biology]. Kompaktwissen Biologie (in German). Berlin, Heidelberg: Springer-Verlag Berlin Heidelberg. doi:10.1007/978-3-662-50274-7. ISBN 978-3-662-50273-0.

Nucleolus organizer regions are chromosomal regions crucial for the formation of the nucleolus, located on the short arms of the acrocentric chromosomes 13, 14, 15, 21 and 22
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Gonzalez IL, Gorski JL, Campen TJ, et al. (1985). "Variation among human 28S ribosomal RNA genes". Proc. Natl. Acad. Sci. U.S.A. 82 (22): 7666–7670. Bibcode:1985PNAS...82.7666G. doi:10.1073/pnas.82.22.7666. PMC 391394. PMID 3865188.
McCallum FS, Maden BE (1986). "Human 18 S ribosomal RNA sequence inferred from DNA sequence. Variations in 18 S sequences and secondary modification patterns between vertebrates". Biochem. J. 232 (3): 725–733. doi:10.1042/bj2320725. PMC 1152944. PMID 4091818.
Financsek I, Mizumoto K, Mishima Y, Muramatsu M (1982). "Human ribosomal RNA gene: nucleotide sequence of the transcription initiation region and comparison of three mammalian genes". Proc. Natl. Acad. Sci. U.S.A. 79 (10): 3092–3096. Bibcode:1982PNAS...79.3092F. doi:10.1073/pnas.79.10.3092. PMC 346359. PMID 6954460.
Gonzalez IL, Sylvester JE (1995). "Complete sequence of the 43-kb human ribosomal DNA repeat: analysis of the intergenic spacer". Genomics. 27 (2): 320–328. doi:10.1006/geno.1995.1049. PMID 7557999.
Gonzalez IL, Sylvester JE (2001). "Human rDNA: evolutionary patterns within the genes and tandem arrays derived from multiple chromosomes". Genomics. 73 (3): 255–263. doi:10.1006/geno.2001.6540. PMID 11350117.

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[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-2] "Entrez Gene: RNR1 RNA, ribosomal 5". Retrieved 2024-08-01.

[Schmidt2017Springer-3] Schmidt, Olaf (2017). Fritsche, Olaf (ed.). Genetik und Molekularbiologie [Genetics and molecular biology]. Kompaktwissen Biologie (in German). Berlin, Heidelberg: Springer-Verlag Berlin Heidelberg. doi:10.1007/978-3-662-50274-7. ISBN 978-3-662-50273-0.

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RNR5

References

Further reading