RRAGB

RRAGB
Identifiers
AliasesRRAGB, RAGB, bA465E19.1, Ras related GTP binding B
External IDsOMIM: 300725; MGI: 3038613; HomoloGene: 48396; GeneCards: RRAGB; OMA:RRAGB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006064
NM_016656

NM_001004154

RefSeq (protein)

NP_006055
NP_057740
NP_001340940
NP_001340942

NP_001004154

Location (UCSC)n/aChr X: 151.92 – 151.95 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Ras-related GTP-binding protein B is a protein that in humans is encoded by the RRAGB gene.[4][5][6]

Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. MTORC1 responds to amino acids via interaction with RAGB.[6]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041658Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Schurmann A, Brauers A, Massmann S, Becker W, Joost HG (Jan 1996). "Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases". J Biol Chem. 270 (48): 28982–8. doi:10.1074/jbc.270.48.28982. PMID 7499430.
  5. ^ Hirose E, Nakashima N, Sekiguchi T, Nishimoto T (Feb 1998). "RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway". J Cell Sci. 111. ( Pt 1): 11–21. doi:10.1242/jcs.111.1.11. PMID 9394008.
  6. ^ a b "Entrez Gene: RRAGB Ras-related GTP binding B".

Further reading

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