SELT

SELENOT
Identifiers
Aliases	SELENOT, SELT, selenoprotein T
External IDs	OMIM: 607912; MGI: 1916477; HomoloGene: 32304; GeneCards: SELENOT; OMA:SELENOT - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	150,630,436 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	58,500,554 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; right adrenal gland; ; right adrenal cortex; ; internal globus pallidus; ; left adrenal gland; ; monocyte; ; beta cell; ; stromal cell of endometrium; ; left adrenal cortex; ; prefrontal cortex;
	Top expressed in
	olfactory epithelium; ; iris; ; median eminence; ; sciatic nerve; ; primitive streak; ; Epithelium of choroid plexus; ; barrel cortex; ; Region I of hippocampus proper; ; vestibular membrane of cochlear duct; ; endothelial cell of lymphatic vessel;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	selenium binding; thioredoxin-disulfide reductase activity; oxidoreductase activity;
Cellular component	endoplasmic reticulum; endoplasmic reticulum membrane; membrane; integral component of membrane;
Biological process	selenocysteine incorporation; positive regulation of cytosolic calcium ion concentration; positive regulation of growth hormone secretion; cellular oxidant detoxification; response to glucose; pancreas development; insulin secretion involved in cellular response to glucose stimulus; glucose homeostasis; cell redox homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	51714
	69227
	ENSG00000198843
	ENSMUSG00000075700
	P62341
	P62342
	NM_016275
	NM_001040396; NM_026997
	NP_057359
	NP_001035486
	Wikidata
View/Edit Human	View/Edit Mouse

Selenoprotein T, also known as SELT, is a protein that in humans is encoded by the SELT gene.^[5]^[6]^[7]

Gene

The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.^[7]

Protein structure

Selenoprotein T contains a selenocysteine (Sec) residue at its active site.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198843 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000075700 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kryukov GV, Kryukov VM, Gladyshev VN (November 1999). "New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements". J. Biol. Chem. 274 (48): 33888–97. doi:10.1074/jbc.274.48.33888. PMID 10567350.
^ Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN (May 2003). "Characterization of mammalian selenoproteomes". Science. 300 (5624): 1439–43. Bibcode:2003Sci...300.1439K. doi:10.1126/science.1083516. PMID 12775843. S2CID 10363908.
^ ^a ^b "Entrez Gene: SELT selenoprotein T".

Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198843 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000075700 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10567350-5] Kryukov GV, Kryukov VM, Gladyshev VN (November 1999). "New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements". J. Biol. Chem. 274 (48): 33888–97. doi:10.1074/jbc.274.48.33888. PMID 10567350.

[pmid12775843-6] Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN (May 2003). "Characterization of mammalian selenoproteomes". Science. 300 (5624): 1439–43. Bibcode:2003Sci...300.1439K. doi:10.1126/science.1083516. PMID 12775843. S2CID 10363908.

[entrez-7] "Entrez Gene: SELT selenoprotein T".

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SELT

Gene

Protein structure

See also

References

Further reading