SGSM2

SGSM2

Identifiers

SGSM2, RUTBC1, small G protein signaling modulator 2

External IDs

OMIM: 611418; MGI: 2144695; HomoloGene: 14780; GeneCards: SGSM2; OMA:SGSM2 - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17p13.3	Start	2,337,498 bp^[1]
Band	17p13.3	End	2,381,058 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 B5	Start	74,740,087 bp^[2]
Band	11\|11 B5	End	74,787,886 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

pancreatic ductal cell

tail of epididymis

endothelial cell

pituitary gland

corpus epididymis

anterior pituitary

right frontal lobe

amygdala

nucleus accumbens

cingulate gyrus

Top expressed in

dentate gyrus of hippocampal formation granule cell

superior frontal gyrus

primary visual cortex

median eminence

arcuate nucleus

subiculum

anterior amygdaloid area

globus pallidus

olfactory tubercle

primary motor cortex

More reference expression data

n/a

Gene ontology
Molecular function	GTPase activator activity
Cellular component	endomembrane system cytoplasm melanosome
Biological process	late endosome to Golgi transport positive regulation of GTPase activity activation of GTPase activity regulation of vesicle fusion intracellular protein transport
Sources:Amigo / QuickGO

Species

Human

Mouse


9905


97761


ENSG00000141258


ENSMUSG00000038351


O43147


Q80U12

RefSeq (mRNA)


NM_001098509 NM_014853 NM_001346700


NM_197943 NM_001374688

RefSeq (protein)


NP_001091979 NP_001333629 NP_055668


NP_922934 NP_001361617

Location (UCSC)

Chr 17: 2.34 – 2.38 Mb

Chr 11: 74.74 – 74.79 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Small G protein signaling modulator 2 is a protein that in humans is encoded by the SGSM2 gene.^[5]^[6]

Clinical relevance

In a recent genome-wide association study, this gene has been associated with fasting glucose traits, type 2 diabetes and obesity.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141258 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038351 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yang, H; et al. (2007). "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway". Genomics. 90 (2): 249–260. doi:10.1016/j.ygeno.2007.03.013. PMID 17509819.
^ "Entrez Gene: small G protein signaling modulator 2".
^ Strawbridge, RJ; et al. (2011-08-26). "Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes". Diabetes. 60 (10): 2624–34. doi:10.2337/db11-0415. PMC 3178302. PMID 21873549.

Further reading

Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
Vasan RS, Glazer NL, Felix JF, et al. (2009). "Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data". JAMA. 302 (2): 168–78. doi:10.1001/jama.2009.978-a. PMC 2975567. PMID 19584346.
Ishikawa K, Nagase T, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
Yang H; Sasaki T; Minoshima S; Shimizu N (2007). "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway". Genomics. 90 (2): 249–60. doi:10.1016/j.ygeno.2007.03.013. PMID 17509819.
Ishibashi K; Kanno E; Itoh T; Fukuda M (2009). "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity". Genes Cells. 14 (1): 41–52. doi:10.1111/j.1365-2443.2008.01251.x. PMID 19077034.

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