SIT1

SIT1
Identifiers
Aliases	SIT1, SIT, SIT-R, signaling threshold regulating transmembrane adaptor 1
External IDs	OMIM: 604964; MGI: 1889342; HomoloGene: 8694; GeneCards: SIT1; OMA:SIT1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	35,650,931 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	43,483,734 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; lymph node; ; blood; ; spleen; ; thymus; ; appendix; ; superficial temporal artery; ; bone marrow cells; ; tonsil; ; mucosa of transverse colon;
	Top expressed in
	thymus; ; mesenteric lymph nodes; ; embryo; ; embryo; ; blood; ; spleen; ; subcutaneous adipose tissue; ; lumbar subsegment of spinal cord; ; granulocyte; ; epiblast;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; SH2 domain binding; kinase binding;
Cellular component	integral component of membrane; integral component of plasma membrane; plasma membrane; extracellular exosome; membrane;
Biological process	adaptive immune response; immune system process; T cell homeostasis; regulation of T cell activation; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	27240
	54390
	ENSG00000137078
	ENSMUSG00000028460
	Q9Y3P8
	Q8C503
	NM_014450
	NM_019436
	NP_055265
	NP_062309
	Wikidata
View/Edit Human	View/Edit Mouse

Signaling threshold-regulating transmembrane adapter 1 is a protein that in humans is encoded by the SIT1 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137078 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028460 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hubener C, Mincheva A, Lichter P, Schraven B, Bruyns E (Aug 2001). "Complete sequence, genomic organization, and chromosomal localization of the human gene encoding the SHP2-interacting transmembrane adaptor protein (SIT)". Immunogenetics. 53 (4): 337–41. doi:10.1007/s002510100328. PMID 11491537. S2CID 34405743.
^ Marie-Cardine A, Kirchgessner H, Bruyns E, Shevchenko A, Mann M, Autschbach F, Ratnofsky S, Meuer S, Schraven B (May 1999). "SHP2-interacting Transmembrane Adaptor Protein (SIT), A Novel Disulfide-linked Dimer Regulating Human T Cell Activation". J Exp Med. 189 (8): 1181–94. doi:10.1084/jem.189.8.1181. PMC 2193021. PMID 10209036.
^ "Entrez Gene: SIT1 signaling threshold regulating transmembrane adaptor 1".

Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
Pfrepper KI, Marie-Cardine A, Simeoni L, et al. (2001). "Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein)". Eur. J. Immunol. 31 (6): 1825–36. doi:10.1002/1521-4141(200106)31:6<1825::AID-IMMU1825>3.0.CO;2-V. PMID 11433379.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ficarro SB, Salomon AR, Brill LM, et al. (2005). "Automated immobilized metal affinity chromatography/nano-liquid chromatography/electrospray ionization mass spectrometry platform for profiling protein phosphorylation sites". Rapid Commun. Mass Spectrom. 19 (1): 57–71. Bibcode:2005RCMS...19...57F. doi:10.1002/rcm.1746. PMID 15570572.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
Tedoldi S, Paterson JC, Hansmann ML, et al. (2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers". Blood. 107 (1): 213–21. doi:10.1182/blood-2005-06-2273. PMID 16160011. S2CID 340034.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137078 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028460 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11491537-5] Hubener C, Mincheva A, Lichter P, Schraven B, Bruyns E (Aug 2001). "Complete sequence, genomic organization, and chromosomal localization of the human gene encoding the SHP2-interacting transmembrane adaptor protein (SIT)". Immunogenetics. 53 (4): 337–41. doi:10.1007/s002510100328. PMID 11491537. S2CID 34405743.

[pmid10209036-6] Marie-Cardine A, Kirchgessner H, Bruyns E, Shevchenko A, Mann M, Autschbach F, Ratnofsky S, Meuer S, Schraven B (May 1999). "SHP2-interacting Transmembrane Adaptor Protein (SIT), A Novel Disulfide-linked Dimer Regulating Human T Cell Activation". J Exp Med. 189 (8): 1181–94. doi:10.1084/jem.189.8.1181. PMC 2193021. PMID 10209036.

[entrez-7] "Entrez Gene: SIT1 signaling threshold regulating transmembrane adaptor 1".

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SIT1

References

Further reading