SOSTDC1

SOSTDC1
Identifiers
AliasesSOSTDC1, ECTODIN, USAG1, CDA019, DAND7, sclerostin domain containing 1
External IDsOMIM: 609675; MGI: 1913292; HomoloGene: 9154; GeneCards: SOSTDC1; OMA:SOSTDC1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015464

NM_025312

RefSeq (protein)

NP_056279

NP_079588

Location (UCSC)Chr 7: 16.46 – 16.53 MbChr 12: 36.36 – 36.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene.[5]

Function

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This gene is a member of the sclerostin family and encodes Uterine sensitization-associated gene-1 (USAG-1), an N-glycosylated, secreted protein with a C-terminal, cystine, knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death.[5]

Inhibition of USAG-1 is of interest as a potential means of stimulating tooth regeneration for dentistry.[6][7][8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171243Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036169Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: SOSTDC1 sclerostin domain containing 1".
  6. ^ Murashima-Suginami A, Kiso H, Tokita Y, Mihara E, Nambu Y, Uozumi R, Tabata Y, Bessho K, Takagi J, Sugai M, Takahashi K (February 2021). "Anti-USAG-1 therapy for tooth regeneration through enhanced BMP signaling". Science Advances. 7 (7). doi:10.1126/sciadv.abf1798. PMC 7880588. PMID 33579703.
  7. ^ Ravi V, Murashima-Suginami A, Kiso H, Tokita Y, Huang CL, Bessho K, Takagi J, Sugai M, Tabata Y, Takahashi K (March 2023). "Advances in tooth agenesis and tooth regeneration". Regenerative Therapy. 22: 160–168. doi:10.1016/j.reth.2023.01.004. PMC 9931762. PMID 36819612.
  8. ^ "World's 1st 'tooth regrowth' medicine moves toward clinical trials in Japan". Mainichi. 12 June 2023.

Further reading

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