Protein-coding gene in the species Homo sapiens
Sulfotransferase family cytosolic 2B member 1 is an enzyme that in humans is encoded by the SULT2B1 gene .[ 5] [ 6]
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones , neurotransmitters , drugs , and xenobiotic chemical compounds . These cytosolic enzymes are different in their tissue distributions and substrate specificities . The gene structure (number and length of exons ) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol , a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000088002 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003271 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Her C, Wood TC, Eichler EE, Mohrenweiser HW, Ramagli LS, Siciliano MJ, Weinshilboum RM (Dec 1998). "Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene". Genomics . 53 (3): 284– 95. doi :10.1006/geno.1998.5518 . PMID 9799594 . ^ a b "Entrez Gene: SULT2B1 sulfotransferase family, cytosolic, 2B, member 1" . Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes" . FASEB J . 11 (1): 3– 14. doi :10.1096/fasebj.11.1.9034160 PMID 9034160 . S2CID 12532583 . Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology". Toxicol. Lett . 112– 113: 341– 8. doi :10.1016/S0378-4274(99)00214-3 . PMID 10720750 . Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics". Chem. Biol. Interact . 129 (1– 2): 141– 70. Bibcode :2000CBI...129..141G . doi :10.1016/S0009-2797(00)00202-7 . PMID 11154739 . Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects". Mutat. Res . 482 (1– 2): 27– 40. doi :10.1016/S0027-5107(01)00207-X . PMID 11535246 . Meloche CA, Falany CN (2001). "Expression and characterization of the human 3 beta-hydroxysteroid sulfotransferases (SULT2B1a and SULT2B1b)". J. Steroid Biochem. Mol. Biol . 77 (4– 5): 261– 9. doi :10.1016/S0960-0760(01)00064-4 . PMID 11457664 . S2CID 20589491 . Geese WJ, Raftogianis RB (2001). "Biochemical characterization and tissue distribution of human SULT2B1". Biochem. Biophys. Res. Commun . 288 (1): 280– 9. doi :10.1006/bbrc.2001.5746 . PMID 11594786 . Fuda H, Lee YC, Shimizu C, et al. (2002). "Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase" . J. Biol. Chem . 277 (39): 36161– 6. doi :10.1074/jbc.M207165200 PMID 12145317 . Pai TG, Sugahara T, Suiko M, et al. (2003). "Differential xenoestrogen-sulfating activities of the human cytosolic sulfotransferases: molecular cloning, expression, and purification of human SULT2B1a and SULT2B1b sulfotransferases". Biochim. Biophys. Acta . 1573 (2): 165– 70. doi :10.1016/s0304-4165(02)00416-6 . PMID 12399026 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Lee KA, Fuda H, Lee YC, et al. (2004). "Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms" . J. Biol. Chem . 278 (45): 44593– 9. doi :10.1074/jbc.M308312200 PMID 12923182 . Yanai H, Javitt NB, Higashi Y, et al. (2004). "Expression of cholesterol sulfotransferase (SULT2B1b) in human platelets". Circulation . 109 (1): 92– 6. doi :10.1161/01.CIR.0000108925.95658.8D . PMID 14676143 . S2CID 14696645 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40– 5. doi :10.1038/ng1285 PMID 14702039 . He D, Meloche CA, Dumas NA, et al. (2004). "Different subcellular localization of sulphotransferase 2B1b in human placenta and prostate" . Biochem. J . 379 (Pt 3): 533– 40. doi :10.1042/BJ20031524 . PMC 1224114 PMID 14741047 . Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" . Nature . 428 (6982): 529– 35. Bibcode :2004Natur.428..529G . doi :10.1038/nature02399 PMID 15057824 . Higashi Y, Fuda H, Yanai H, et al. (2004). "Expression of cholesterol sulfotransferase (SULT2B1b) in human skin and primary cultures of human epidermal keratinocytes" . J. Invest. Dermatol . 122 (5): 1207– 13. doi :10.1111/j.0022-202X.2004.22416.x PMID 15140224 .
PDB gallery
1q1q : Crystal structure of human pregnenolone sulfotransferase (SULT2B1a) in the presence of PAP
1q1z : Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of PAP
1q20 : Crystal Structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of PAP and pregnenolone
1q22 : Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of DHEA and PAP
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