Sjögren syndrome antigen B

SSB

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1OWX, 1S79, 1S7A, 1YTY, 1ZH5, 2VOD, 2VON, 2VOO, 2VOP

Identifiers

SSB, LARP3, La, La/Sjogren syndrome antigen B, small RNA binding exonuclease protection factor La

External IDs

OMIM: 109090; MGI: 98423; HomoloGene: 2366; GeneCards: SSB; OMA:SSB - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q31.1	Start	169,791,933 bp^[1]
Band	2q31.1	End	169,812,064 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2 C2\|2 40.95 cM	Start	69,691,906 bp^[2]
Band	2 C2\|2 40.95 cM	End	69,702,190 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

tendon of biceps brachii

Achilles tendon

ventricular zone

mucosa of paranasal sinus

monocyte

epithelium of nasopharynx

ganglionic eminence

peritoneum

left coronary artery

anterior pituitary

Top expressed in

tail of embryo

genital tubercle

maxillary prominence

mandibular prominence

ventricular zone

embryo

embryo

abdominal wall

supraoptic nucleus

ganglionic eminence

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding mRNA binding nucleic acid binding tRNA binding RNA binding poly(U) RNA binding protein homodimerization activity sequence-specific mRNA binding
Cellular component	nucleus cytoplasm ribonucleoprotein complex
Biological process	RNA processing histone mRNA metabolic process protein localization to cytoplasmic stress granule tRNA modification IRES-dependent viral translational initiation tRNA 5'-leader removal tRNA export from nucleus tRNA processing tRNA 3'-end processing nuclear histone mRNA catabolic process
Sources:Amigo / QuickGO

Species

Human

Mouse


6741


20823


ENSG00000138385


ENSMUSG00000068882


P05455


P32067

RefSeq (mRNA)


NM_003142 NM_001294145


NM_001110145 NM_009278 NM_001355265

RefSeq (protein)


NP_001281074 NP_003133


NP_001103615 NP_033304 NP_001342194

Location (UCSC)

Chr 2: 169.79 – 169.81 Mb

Chr 2: 69.69 – 69.7 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Sjögren syndrome type B antigen (SS-B) also known as Lupus La protein is a protein that in humans is encoded by the SSB gene.^[5]

Function

La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjögren's syndrome and systemic lupus erythematosus.^[5]^[6]

Interactions

Sjögren syndrome antigen B has been shown to interact with nucleolin.^[7]

See also

La domain

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138385 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068882 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: SSB Sjögren's syndrome antigen B (autoantigen La)".
^ Teplova M, Yuan YR, Phan AT, Malinina L, Ilin S, Teplov A, Patel DJ (January 2006). "Structural basis for recognition and sequestration of UUU(OH) 3' temini of nascent RNA polymerase III transcripts by La, a rheumatic disease autoantigen". Molecular Cell. 21 (1): 75–85. doi:10.1016/j.molcel.2005.10.027. PMC 4689297. PMID 16387655.
^ Fouraux MA, Bouvet P, Verkaart S, van Venrooij WJ, Pruijn GJ (July 2002). "Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes". Journal of Molecular Biology. 320 (3): 475–88. doi:10.1016/S0022-2836(02)00518-1. hdl:2066/121576. PMID 12096904.

Further reading

Kohsaka H, Yamamoto K, Fujii H, Miura H, Miyasaka N, Nishioka K, Miyamoto T (May 1990). "Fine epitope mapping of the human SS-B/La protein. Identification of a distinct autoepitope homologous to a viral gag polyprotein". The Journal of Clinical Investigation. 85 (5): 1566–74. doi:10.1172/JCI114606. PMC 296607. PMID 1692037.
Sturgess AD, Peterson MG, McNeilage LJ, Whittingham S, Coppel RL (May 1988). "Characteristics and epitope mapping of a cloned human autoantigen La". Journal of Immunology. 140 (9): 3212–8. doi:10.4049/jimmunol.140.9.3212. PMID 2452201. S2CID 1863804.
Rauh AJ, Hornig H, Lührmann R (December 1988). "At least three distinct B cell epitopes reside in the C-terminal half of La protein, as determined by a recombinant DNA approach". European Journal of Immunology. 18 (12): 2049–57. doi:10.1002/eji.1830181227. PMID 2464497. S2CID 7014818.
Chan EK, Sullivan KF, Tan EM (March 1989). "Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding". Nucleic Acids Research. 17 (6): 2233–44. doi:10.1093/nar/17.6.2233. PMC 317593. PMID 2468131.
Gottlieb E, Steitz JA (March 1989). "Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III". The EMBO Journal. 8 (3): 851–61. doi:10.1002/j.1460-2075.1989.tb03446.x. PMC 400884. PMID 2470590.
Chambers JC, Kenan D, Martin BJ, Keene JD (December 1988). "Genomic structure and amino acid sequence domains of the human La autoantigen". The Journal of Biological Chemistry. 263 (34): 18043–51. doi:10.1016/S0021-9258(19)81321-2. PMID 3192525.
Chambers JC, Keene JD (April 1985). "Isolation and analysis of cDNA clones expressing human lupus La antigen". Proceedings of the National Academy of Sciences of the United States of America. 82 (7): 2115–9. Bibcode:1985PNAS...82.2115C. doi:10.1073/pnas.82.7.2115. PMC 397503. PMID 3856888.
Svitkin YV, Pause A, Sonenberg N (November 1994). "La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA". Journal of Virology. 68 (11): 7001–7. doi:10.1128/jvi.68.11.7001-7007.1994. PMC 237137. PMID 7933082.
Tröster H, Metzger TE, Semsei I, Schwemmle M, Winterpacht A, Zabel B, Bachmann M (December 1994). "One gene, two transcripts: isolation of an alternative transcript encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary Sjögrens' syndrome". The Journal of Experimental Medicine. 180 (6): 2059–67. doi:10.1084/jem.180.6.2059. PMC 2191769. PMID 7964483.
Fan H, Sakulich AL, Goodier JL, Zhang X, Qin J, Maraia RJ (March 1997). "Phosphorylation of the human La antigen on serine 366 can regulate recycling of RNA polymerase III transcription complexes". Cell. 88 (5): 707–15. doi:10.1016/S0092-8674(00)81913-3. PMID 9054510. S2CID 2223069.
McLaren RS, Caruccio N, Ross J (June 1997). "Human La protein: a stabilizer of histone mRNA". Molecular and Cellular Biology. 17 (6): 3028–36. doi:10.1128/mcb.17.6.3028. PMC 232155. PMID 9154801.
Grölz D, Bachmann M (April 1997). "The nuclear autoantigen La/SS-associated antigen B: one gene, three functional mRNAs". The Biochemical Journal. 323 ( Pt 1) (1): 151–8. doi:10.1042/bj3230151. PMC 1218288. PMID 9173875.
Helsloot J, Sturgess A (December 1997). "T cell reactivity to Sjögren's syndrome related antigen La(SSB)". The Journal of Rheumatology. 24 (12): 2340–7. PMID 9415639.
Broekhuis CH, Neubauer G, van der Heijden A, Mann M, Proud CG, van Venrooij WJ, Pruijn GJ (March 2000). "Detailed analysis of the phosphorylation of the human La (SS-B) autoantigen. (De)phosphorylation does not affect its subcellular distribution". Biochemistry. 39 (11): 3023–33. doi:10.1021/bi992308c. hdl:2066/187036. PMID 10715123.
Spångberg K, Wiklund L, Schwartz S (September 2000). "HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities". Virology. 274 (2): 378–90. doi:10.1006/viro.2000.0461. PMID 10964780.
Intine RV, Sakulich AL, Koduru SB, Huang Y, Pierstorff E, Goodier JL, Phan L, Maraia RJ (August 2000). "Control of transfer RNA maturation by phosphorylation of the human La antigen on serine 366". Molecular Cell. 6 (2): 339–48. doi:10.1016/S1097-2765(00)00034-4. PMID 10983981.
Nashimoto M, Nashimoto C, Tamura M, Kaspar RL, Ochi K (October 2001). "The inhibitory effect of the autoantigen La on in vitro 3' processing of mammalian precursor tRNAs". Journal of Molecular Biology. 312 (5): 975–84. doi:10.1006/jmbi.2001.5026. PMID 11580243.
De Nova-Ocampo M, Villegas-Sepúlveda N, del Angel RM (April 2002). "Translation elongation factor-1alpha, La, and PTB interact with the 3' untranslated region of dengue 4 virus RNA". Virology. 295 (2): 337–47. doi:10.1006/viro.2002.1407. PMID 12033793.
Intine RV, Dundr M, Misteli T, Maraia RJ (May 2002). "Aberrant nuclear trafficking of La protein leads to disordered processing of associated precursor tRNAs". Molecular Cell. 9 (5): 1113–23. doi:10.1016/S1097-2765(02)00533-6. PMID 12049746.
Fouraux MA, Bouvet P, Verkaart S, van Venrooij WJ, Pruijn GJ (July 2002). "Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes". Journal of Molecular Biology. 320 (3): 475–88. doi:10.1016/S0022-2836(02)00518-1. hdl:2066/121576. PMID 12096904.

PDB gallery

1owx: Solution structure of the C-terminal RRM of human La (La225-334)
1s79: Solution structure of the central RRM of human La protein
1s7a: NMR structure of the La motif of human La protein
1yty: Structural basis for recognition of UUUOH 3'-termini of nascent RNA pol III transcripts by La autoantigen
1zh5: Structural basis for recognition of UUUOH 3'-termini of nascent RNA pol III transcripts by La autoantigen

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