Portrait | Office | Name | Term | Party | Undersecretaries |
| Prime Minister | Giovanni Spadolini | 23 August 1982 – 1 December 1982 | | Italian Republican Party | Vittorio Olcese (PRI)[a] |
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| Minister of Foreign Affairs | Emilio Colombo | 23 August 1982 – 1 December 1982 | | Christian Democracy | Bruno Corti (PSDI) Raffaele Costa (PLI) Mario Fioret (DC) Roberto Palleschi (PSI) |
| Minister of the Interior | Virginio Rognoni | 23 August 1982 – 1 December 1982 | | Christian Democracy | Marino Corder (DC) Angelo Maria Sanza (DC) Francesco Spinelli (PSI) |
| Minister of Grace and Justice | Clelio Darida | 23 August 1982 – 1 December 1982 | | Christian Democracy | Giuseppe Gargani (DC) Domenico Raffaello Lombardi (DC) Gaetano Scamarcio (PSI) |
| Minister of Budget and Economic Planning | Giorgio La Malfa | 23 August 1982 – 1 December 1982 | | Italian Republican Party | Emilio Rubbi (DC) |
| Minister of Finance | Rino Formica | 23 August 1982 – 1 December 1982 | | Italian Socialist Party | Giuseppe Amadei (PSDI) Francesco Colucci (PSI) Paolo Enrico Moro (DC) Rodolfo Tambroni Armaroli (DC) |
| Minister of Treasury | Beniamino Andreatta | 23 August 1982 – 1 December 1982 | | Christian Democracy | Carlo Fracanzani (DC) Giuseppe Pisanu (DC) Eugenio Tarabini (DC) Angelo Tiraboschi (PSI) Claudio Venanzetti (PRI) |
| Minister of Defence | Lelio Lagorio | 23 August 1982 – 1 December 1982 | | Italian Socialist Party | Bartolomeo Ciccardini (DC) Martino Scovacricchi (PSDI) Amerigo Petrucci (DC) |
| Minister of Public Education | Guido Bodrato | 23 August 1982 – 1 December 1982 | | Christian Democracy | Antonino Drago (DC) Franca Falcucci (DC) Giuseppe Fassino (PLI) Sisinio Zito (PSI) |
| Minister of Public Works | Franco Nicolazzi | 23 August 1982 – 1 December 1982 | | Italian Democratic Socialist Party | Mario Casalinuovo (PSI) Giorgio Santuz (DC) |
| Minister of Agriculture and Forests | Giuseppe Bartolomei | 23 August 1982 – 1 December 1982 | | Christian Democracy | Mario Campagnoli (DC) Fabio Fabbri (PSI) |
| Minister of Transport | Vincenzo Balzamo | 23 August 1982 – 1 December 1982 | | Italian Socialist Party | Antonio Caldoro (PSI) Dino Riva (PSDI) Elio Tiriolo (DC) |
| Minister of Post and Telecommunications | Remo Gaspari | 23 August 1982 – 1 December 1982 | | Christian Democracy | Giorgio Bogi (PRI) Pino Leccisi (DC) Gaspare Saladino (PSI) |
| Minister of Industry, Commerce and Craftsmanship | Giovanni Marcora | 23 August 1982 – 1 December 1982 | | Christian Democracy | Gianni Fontana (DC) Enrico Novellini (PSI) Francesco Rebecchini (DC) |
| Minister of Health | Renato Altissimo | 23 August 1982 – 1 December 1982 | | Italian Liberal Party | Maria Magnani Noya (PSI) Bruno Orsini (DC) |
| Minister of Foreign Trade | Nicola Capria | 23 August 1982 – 1 December 1982 | | Italian Socialist Party | Baldassare Armato (DC) Enrico Rizzi (PSDI) |
| Minister of Merchant Navy | Calogero Mannino | 23 August 1982 – 1 December 1982 | | Christian Democracy | Giovanni Nonne (PSI) Francesco Patriarca (DC) |
| Minister of State Holdings | Gianni De Michelis | 23 August 1982 – 1 December 1982 | | Italian Socialist Party | Silvestro Ferrari (DC) Delio Giacometti (DC) |
| Minister of Labour and Social Security | Michele Di Giesi | 23 August 1982 – 1 December 1982 | | Italian Democratic Socialist Party | Mario Costa (DC) Angelo Cresco (PSI) Mario Gargano (DC) Piergiovanni Malvestio (DC) |
| Minister of Cultural and Environmental Heritage | Vincenzo Scotti | 23 August 1982 – 1 December 1982 | | Christian Democracy | Pietro Mezzapesa (DC) |
| Minister of Tourism and Entertainment | Nicola Signorello | 23 August 1982 – 1 December 1982 | | Christian Democracy | Enrico Quaranta (PSI) |
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| Minister of Regional Affairs (without portfolio) | Aldo Aniasi | 23 August 1982 – 1 December 1982 | | Italian Socialist Party | |
| Minister for the Coordination of Scientific and Technological Research (without portfolio) | Giancarlo Tesini | 23 August 1982 – 1 December 1982 | | Christian Democracy | |
| Minister for the Coordination of Community Policies (without portfolio) | Lucio Abis | 23 August 1982 – 1 December 1982 | | Christian Democracy | |
| Minister for the Coordination of Civil Protection (without portfolio) | Giuseppe Zamberletti | 23 August 1982 – 1 December 1982 | | Christian Democracy | |
| Minister of Public Function (without portfolio) | Dante Schietroma | 23 August 1982 – 1 December 1982 | | Italian Democratic Socialist Party | Francesco Quattrone (DC) |
| Minister for Extraordinary Interventions in the South (without portfolio) | Claudio Signorile | 23 August 1982 – 1 December 1982 | | Italian Socialist Party | Salvatore Urso (DC) |
| Minister for Parliamentary Relations (without portfolio) | Luciano Radi | 23 August 1982 – 1 December 1982 | | Christian Democracy | |