Protein-coding gene in the species Homo sapiens
Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene .[ 5] [ 6] [ 7]
TRAP1 has been shown to interact with EXT2 ,[ 8] EXT1 [ 8] Retinoblastoma protein .[ 9]
^ a b c GRCh38: Ensembl release 89: ENSG00000126602 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005981 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Felts SJ, Owen BA, Nguyen P, Trepel J, Donner DB, Toft DO (March 2000). "The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties" . J Biol Chem . 275 (5): 3305–12. doi :10.1074/jbc.275.5.3305 PMID 10652318 . ^ Song HY, Dunbar JD, Zhang YX, Guo D, Donner DB (March 1995). "Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor" . J Biol Chem . 270 (8): 3574–81. doi :10.1074/jbc.270.8.3574 PMID 7876093 . ^ "Entrez Gene: TRAP1 TNF receptor-associated protein 1" .^ a b Simmons, A D; Musy M M; Lopes C S; Hwang L Y; Yang Y P; Lovett M (November 1999). "A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses" . Hum. Mol. Genet . 8 (12): 2155–64. doi :10.1093/hmg/8.12.2155 ISSN 0964-6906 . PMID 10545594 . ^ Chen, C F; Chen Y; Dai K; Chen P L; Riley D J; Lee W H (September 1996). "A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock" . Mol. Cell. Biol . 16 (9): 4691–9. doi :10.1128/MCB.16.9.4691 . ISSN 0270-7306 . PMC 231469 PMID 8756626 . Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Chen CF, Chen Y, Dai K, et al. (1996). "A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock" . Mol. Cell. Biol . 16 (9): 4691–9. doi :10.1128/MCB.16.9.4691 . PMC 231469 PMID 8756626 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Charng MJ, Zhang D, Kinnunen P, Schneider MD (1998). "A novel protein distinguishes between quiescent and activated forms of the type I transforming growth factor beta receptor" . J. Biol. Chem . 273 (16): 9365–8. doi :10.1074/jbc.273.16.9365 PMID 9545258 . Simmons AD, Musy MM, Lopes CS, et al. (1999). "A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses" . Hum. Mol. Genet . 8 (12): 2155–64. doi :10.1093/hmg/8.12.2155 PMID 10545594 . Wurthner JU, Frank DB, Felici A, et al. (2001). "Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone" . J. Biol. Chem . 276 (22): 19495–502. doi :10.1074/jbc.M006473200 PMID 11278302 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Masuda Y, Shima G, Aiuchi T, et al. (2004). "Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin" . J. Biol. Chem . 279 (41): 42503–15. doi :10.1074/jbc.M404256200 PMID 15292218 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Brown V, Brown RA, Ozinsky A, et al. (2006). "Binding specificity of Toll-like receptor cytoplasmic domains" . Eur. J. Immunol . 36 (3): 742–53. doi :10.1002/eji.200535158 . PMC 2762736 PMID 16482509 . Im CN, Lee JS, Zheng Y, Seo JS (2007). "Iron chelation study in a normal human hepatocyte cell line suggests that tumor necrosis factor receptor-associated protein 1 (TRAP1) regulates production of reactive oxygen species". J. Cell. Biochem . 100 (2): 474–86. doi :10.1002/jcb.21064 . PMID 16927372 . S2CID 12489077 .
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