Ternary complex

A ternary complex is a protein complex containing three different molecules that are bound together. In structural biology, ternary complex can also be used to describe a crystal containing a protein with two small molecules bound, such as a cofactor and a substrate; or a complex formed between two proteins and a single substrate.^[1] In Immunology, ternary complex can refer to the MHC–peptide–T-cell-receptor complex formed when T cells recognize epitopes of an antigen. Another important example is the ternary complex formed during eukaryotic translation, in which ternary complex composed of eIF2 + GTP + Met-tRNA_i^Met is formed.^[2] A ternary complex can be a complex formed between two substrate molecules and an enzyme. This is seen in multi-substrate enzyme-catalyzed reactions where two substrates and two products can be formed. The ternary complex is an intermediate species in this type of enzyme-catalyzed reaction. An example for a ternary complex is seen in the random-order mechanism or the compulsory-order mechanism of enzyme catalysis for multiple substrates.^[3]

The term ternary complex can also refer to a polymer formed by electrostatic interactions.^[4]

References

^ Clar, Steven G.; Tamanoi, Fuyuhiko (2006). Protein methyltransferass. Academic Press. pp. 162–172. ISBN 978-0-12-122725-8.
^ Robert, Francis; Kapp, Lee D.; Khan, Shakila N.; Acker, Michael G.; Kolitz, Sarah; Kazemi, Shirin; Kaufman, Randal J.; Merrick, William C.; Koromilas, Antonis E.; Lorsch, Jon R.; Pelletier, Jerry (November 2006). Schmid, Sandra (ed.). "Initiation of Protein Synthesis by Hepatitis C Virus Is Refractory to Reduced eIF2 · GTP · Met-tRNA i Met Ternary Complex Availability". Molecular Biology of the Cell. 17 (11): 4632–4644. doi:10.1091/mbc.e06-06-0478. ISSN 1059-1524. PMC 1635388. PMID 16928960.
^ Hindson, V. John; Shaw, William V. (2003-03-01). "Random-Order Ternary Complex Reaction Mechanism of Serine Acetyltransferase from Escherichia coli". Biochemistry. 42 (10): 3113–3119. doi:10.1021/bi0267893. ISSN 0006-2960. PMID 12627979.
^ Cabuil, Valérie; Levitz, Pierre; Treiner, Clande (2004). Trends in colloid and interface science XVII. Springer. p. 45. ISBN 978-3-540-20073-4.

Trevor Palmer (Enzymes, 2nd edition)

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[1] Clar, Steven G.; Tamanoi, Fuyuhiko (2006). Protein methyltransferass. Academic Press. pp. 162–172. ISBN 978-0-12-122725-8.

[2] Robert, Francis; Kapp, Lee D.; Khan, Shakila N.; Acker, Michael G.; Kolitz, Sarah; Kazemi, Shirin; Kaufman, Randal J.; Merrick, William C.; Koromilas, Antonis E.; Lorsch, Jon R.; Pelletier, Jerry (November 2006). Schmid, Sandra (ed.). "Initiation of Protein Synthesis by Hepatitis C Virus Is Refractory to Reduced eIF2 · GTP · Met-tRNA i Met Ternary Complex Availability". Molecular Biology of the Cell. 17 (11): 4632–4644. doi:10.1091/mbc.e06-06-0478. ISSN 1059-1524. PMC 1635388. PMID 16928960.

[3] Hindson, V. John; Shaw, William V. (2003-03-01). "Random-Order Ternary Complex Reaction Mechanism of Serine Acetyltransferase from Escherichia coli". Biochemistry. 42 (10): 3113–3119. doi:10.1021/bi0267893. ISSN 0006-2960. PMID 12627979.

[4] Cabuil, Valérie; Levitz, Pierre; Treiner, Clande (2004). Trends in colloid and interface science XVII. Springer. p. 45. ISBN 978-3-540-20073-4.

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