Triphenylethanol

Triphenylethanol
Names
Preferred IUPAC name
1,1,2-Triphenylethan-1-ol
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • InChI=1S/C20H18O/c21-20(18-12-6-2-7-13-18,19-14-8-3-9-15-19)16-17-10-4-1-5-11-17/h1-15,21H,16H2
    Key: QMPKJVBRCQVFLL-UHFFFAOYSA-N
  • C1=CC=C(C=C1)CC(C2=CC=CC=C2)(C3=CC=CC=C3)O
Properties
C20H18O
Molar mass 274.363 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Triphenylethanol, or 1,1,2-triphenylethanol, is an organic compound with a condensed structural formula of (C
6H
5)
2C(OH)CH
2C
6H
5, and is related to triphenylethylene, from which it can be prepared by hydration. It is the structural analog of two drugs, the never-marketed antiestrogen ethamoxytriphetol (MER-25)[1]: 7  and the withdrawn lipid-lowering agent triparanol,[2] as both contain the 1,1,2-triphenylethanol moiety within their structure.

There are three isomeric compounds with a "triphenylethanol" structure:

  • 1,1,2-triphenylethanol;
  • 1,2,2-triphenylethanol, with a condensed structural formula of (C
    6    H
    5    )
    2    CHCH(C
    6    H
    5    )OH    , which exists as a pair of enantiomers; and,
  • 2,2,2-triphenylethanol, with a condensed structural formula of (C
    6    H
    5    )
    3    CCH
    2    OH    .

References

[edit]
  1. ^ Jordan, V. Craig (2013). "A Century of Deciphering the Control Mechanisms of Estrogen Action in Breast Cancer: The Origins of Targeted Therapy and Chemoprevention". In Jordan, V. Craig (ed.). Estrogen Action, Selective Estrogen Receptor Modulators and Women's Health: Progress and Promise. World Scientific. pp. 1–29. ISBN 978-1-84816-959-3.
  2. ^ Bulletin of the National Institute of Sciences of India. National Institute of Sciences of India. 1964. p. 5.


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