گلوکز ۶-فسفات ایزومراز (انگلیسی: Glucose-6-phosphate isomerase) یا فسفوگلوکز ایزومراز یا عامل تحرک اُتوکرین[۳] یکی از آنزیمهای چرخه قندکافت است که گلوکز ۶-فسفات را به فروکتوز ۶-فسفات تبدیل میکند.
این آنزیم توسط سلولهای سرطانی هم ترشح میشود و یکی از عوامل پخش شدن آنها و بروز متاستاز است.[۴]
Walker JI, Faik P, Morgan MJ (1990). "Characterization of the 5' end of the gene for human glucose phosphate isomerase (GPI)". Genomics. 7 (4): 638–43. doi:10.1016/0888-7543(90)90212-D. PMID2387591.
Brownstein BH, Silverman GA, Little RD, et al. (1989). "Isolation of single-copy human genes from a library of yeast artificial chromosome clones". Science. 244 (4910): 1348–51. doi:10.1126/science.2544027. PMID2544027.
Mizrachi Y (1989). "Neurotrophic activity of monomeric glucophosphoisomerase was blocked by human immunodeficiency virus (HIV-1) and peptides from HIV-1 envelope glycoprotein". J. Neurosci. Res. 23 (2): 217–24. doi:10.1002/jnr.490230212. PMID2547084.
Gurney ME, Apatoff BR, Spear GT, et al. (1986). "Neuroleukin: a lymphokine product of lectin-stimulated T cells". Science. 234 (4776): 574–81. doi:10.1126/science.3020690. PMID3020690.
Faik P, Walker JI, Redmill AA, Morgan MJ (1988). "Mouse glucose-6-phosphate isomerase and neuroleukin have identical 3' sequences". Nature. 332 (6163): 455–7. doi:10.1038/332455a0. PMID3352745.
Zanella A, Izzo C, Rebulla P, et al. (1981). "The first stable variant of erythrocyte glucose-phosphate isomerase associated with severe hemolytic anemia". Am. J. Hematol. 9 (1): 1–11. doi:10.1002/ajh.2830090102. PMID7435496.
Faik P, Walker JI, Morgan MJ (1994). "Identification of a novel tandemly repeated sequence present in an intron of the glucose phosphate isomerase (GPI) gene in mouse and man". Genomics. 21 (1): 122–7. doi:10.1006/geno.1994.1233. PMID7545951.
Xu W, Lee P, Beutler E (1996). "Human glucose phosphate isomerase: exon mapping and gene structure". Genomics. 29 (3): 732–9. doi:10.1006/geno.1995.9944. PMID8575767.
Baronciani L, Zanella A, Bianchi P, et al. (1996). "Study of the molecular defects in glucose phosphate isomerase-deficient patients affected by chronic hemolytic anemia". Blood. 88 (6): 2306–10. PMID8822952.
Beutler E, West C, Britton HA, et al. (1998). "Glucosephosphate isomerase (GPI) deficiency mutations associated with hereditary nonspherocytic hemolytic anemia (HNSHA)". Blood Cells Mol. Dis. 23 (3): 402–9. doi:10.1006/bcmd.1997.0157. PMID9446754.
Kanno H, Fujii H, Miwa S (1998). "Expression and enzymatic characterization of human glucose phosphate isomerase (GPI) variants accounting for GPI deficiency". Blood Cells Mol. Dis. 24 (1): 54–61. doi:10.1006/bcmd.1998.0170. PMID9616041.
Kugler W, Breme K, Laspe P, et al. (1998). "Molecular basis of neurological dysfunction coupled with haemolytic anaemia in human glucose-6-phosphate isomerase (GPI) deficiency". Hum. Genet. 103 (4): 450–4. doi:10.1007/s004390050849. PMID9856489.
Belyaeva OV, Balanovsky OP, Ashworth LK, et al. (1999). "Fine mapping of a polymorphic CA repeat marker on human chromosome 19 and its use in population studies". Gene. 230 (2): 259–66. doi:10.1016/S0378-1119(99)00056-6. PMID10216265.
Yakirevich E, Naot Y (2000). "Cloning of a glucose phosphate isomerase/neuroleukin-like sperm antigen involved in sperm agglutination". Biol. Reprod. 62 (4): 1016–23. doi:10.1095/biolreprod62.4.1016. PMID10727272.
Haga A, Niinaka Y, Raz A (2000). "Phosphohexose isomerase/autocrine motility factor/neuroleukin/maturation factor is a multifunctional phosphoprotein". Biochim. Biophys. Acta. 1480 (1–2): 235–44. doi:10.1016/s0167-4838(00)00075-3. PMID11004567.
1dqr: CRYSTAL STRUCTURE OF RABBIT PHOSPHOGLUCOSE ISOMERASE, A GLYCOLYTIC ENZYME THAT MOONLIGHTS AS NEUROLEUKIN, AUTOCRINE MOTILITY FACTOR, AND DIFFERENTIATION MEDIATOR
1g98: CRYSTAL STRUCTURE ANALYSIS OF RABBIT PHOSPHOGLUCOSE ISOMERASE COMPLEXED WITH 5-PHOSPHOARABINONATE, A TRANSITION STATE ANALOGUE
1gzd: CRYSTAL STRUCTURE OF PIG PHOSPHOGLUCOSE ISOMERASE
1gzv: THE CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE ISOMERASE FROM PIG MUSCLE COMPLEXED WITH 5-PHOSPHOARABINONATE
1hm5: CRYSTAL STRUCTURE ANALYSIS OF THE RABBIT D-GLUCOSE 6-PHOSPHATE ISOMERASE (NO LIGAND BOUND)
1hox: CRYSTAL STRUCTURE OF RABBIT PHOSPHOGLUCOSE ISOMERASE COMPLEXED WITH FRUCTOSE-6-PHOSPHATE
1iat: CRYSTAL STRUCTURE OF HUMAN PHOSPHOGLUCOSE ISOMERASE/NEUROLEUKIN/AUTOCRINE MOTILITY FACTOR/MATURATION FACTOR
1iri: Crystal structure of human autocrine motility factor complexed with an inhibitor
1jiq: Crystal Structure of Human Autocrine Motility Factor
1jlh: Human Glucose-6-phosphate Isomerase
1koj: Crystal structure of rabbit phosphoglucose isomerase complexed with 5-phospho-D-arabinonohydroxamic acid
1n8t: The crystal structure of phosphoglucose isomerase from rabbit muscle
1nuh: The crystal structure of human phosphoglucose isomerase complexed with 5-phosphoarabinonate
1xtb: Crystal Structure of Rabbit Phosphoglucose Isomerase Complexed with Sorbitol-6-Phosphate
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