FOXA1 - ویکی‌پدیا، دانشنامهٔ آزاد

FOXA1
معین‌کننده‌ها
نام‌های دیگر	FOXA1, HNF3A, TCF3A, forkhead box A1
شناسه‌های بیرونی	OMIM: 602294 MGI: 1347472 HomoloGene: 3307 GeneCards: FOXA1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۲ (موش)
پایان	57,593,702 bp
هستی‌شناسی ژن
عملکرد ملکولی	• sequence-specific DNA binding; • protein domain specific binding; • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • transcription factor binding; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • DNA binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
ترکیبات سلولی	• ریزپرز; • هسته یاخته; • fibrillar center; • نوکلئوپلاسم;
فرایند زیستی	• Notch signaling pathway; • prostate gland stromal morphogenesis; • dopaminergic neuron differentiation; • positive regulation of intracellular estrogen receptor signaling pathway; • response to estradiol; • GO:0009373 regulation of transcription, DNA-templated; • lung morphogenesis; • glucose homeostasis; • positive regulation of smoothened signaling pathway; • lung development; • GO:0044324، GO:0003256، GO:1901213، GO:0046019، GO:0046020، GO:1900094، GO:0061216، GO:0060994، GO:1902064، GO:0003258، GO:0072212 regulation of transcription by RNA polymerase II; • neuron fate specification; • anatomical structure formation involved in morphogenesis; • positive regulation of mitotic cell cycle; • positive regulation of DNA-binding transcription factor activity; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription by RNA polymerase II; • tube morphogenesis; • secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; • transcription, DNA-templated; • regulation of cell cycle; • multicellular organism development; • prostate gland epithelium morphogenesis; • connective tissue development; • positive regulation of neuron differentiation; • epithelial cell maturation involved in prostate gland development; • ساماندهی بیان ژن; • lung epithelial cell differentiation; • dorsal/ventral neural tube patterning; • epithelial-mesenchymal signaling involved in prostate gland development; • epithelial tube branching involved in lung morphogenesis; • respiratory basal cell differentiation; • hormone metabolic process; • alveolar secondary septum development; • negative regulation of epithelial to mesenchymal transition; • positive regulation of cell-cell adhesion mediated by cadherin; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • chromatin remodeling; • anatomical structure morphogenesis; • positive regulation of apoptotic process; • GO:0031497، GO:0006336، GO:0034724، GO:0001301، GO:0007580، GO:0034652، GO:0010847 chromatin organization; • دگرگونی یاخته‌;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	3169
	15375
	ENSG00000129514
	ENSMUSG00000035451
	P55317
	P35582
	NM_004496
	XM_006515479، XM_006515481، XM_006515483، XM_017314962، XM_030246562 NM_008259، XM_006515479، XM_006515481، XM_006515483، XM_017314962، XM_030246562
	XP_016876735 NP_004487، XP_016876735
	XP_006515542، XP_006515544، XP_006515546، XP_017170451، XP_030102422 NP_032285، XP_006515542، XP_006515544، XP_006515546، XP_017170451، XP_030102422
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین A1 جعبه سرچنگالی (به انگلیسی: Forkhead box protein A1) یا به اختصار FOXA1 که با نام فاکتور ۳-آلفا هسته‌ای هپاتوسیت (HNF-3A) هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «FOXA1» کُدگذاری می‌شود.^[۴]^[۵]^[۶]

عملکرد

این پروتئین یکی از اعضای خانوادهٔ پروتئین‌های FOX است که به دی‌ان‌ای متصل می‌شوند و فعال‌کننده‌های رونویسی مولکول‌های خاص کبدی همچون آلبومین و ترانس‌تیرتین هستند و با کروماتین نیز واکنش نشان می‌دهند. این پروتئین همچنین یک نشانگر زیستی در سرطان پستان است.

اهمیت بالینی

جهش در ژن «FOXA1» سرطان پروستات مشاهده شده‌است.^[۷] میزان بیانِ این ژن همچنین با دو نشانگر زیستی دیگر در سرطان پستان (یعنی ئی-کادهرین و TWIST1) مطابقت دارد.^[۸]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000035451 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: forkhead box A1".
↑ Bingle CD, Gowan S (1996). "Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line". Biochim Biophys Acta. 1307 (1): 17–20. doi:10.1016/0167-4781(96)00058-9. PMID 8652662.
↑ Mincheva A, Lichter P, Schütz G, Kaestner KH (1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics. 39 (3): 417–9. doi:10.1006/geno.1996.4477. PMID 9119385.
↑ Barbieri CE, Baca SC, Lawrence MS, Demichelis F, Blattner M, Theurillat JP, White TA, Stojanov P, Van Allen E, Stransky N, Nickerson E, Chae SS, Boysen G, Auclair D, Onofrio RC, Park K, Kitabayashi N, MacDonald TY, Sheikh K, Vuong T, Guiducci C, Cibulskis K, Sivachenko A, Carter SL, Saksena G, Voet D, Hussain WM, Ramos AH, Winckler W, Redman MC, Ardlie K, Tewari AK, Mosquera JM, Rupp N, Wild PJ, Moch H, Morrissey C, Nelson PS, Kantoff PW, Gabriel SB, Golub TR, Meyerson M, Lander ES, Getz G, Rubin MA, Garraway LA (June 2012). "Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer". Nat. Genet. 44 (6): 685–9. doi:10.1038/ng.2279. PMC 3673022. PMID 22610119.
↑ BenAyed-Guerfali, Dorra; Dabbèche-Bouricha, Emna; Ayadi, Wajdi; Trifa, Fatma; Charfi, Slim; Khabir, Abdelmajid; Sellami-Boudawara, Tahia; Mokdad-Gargouri, Raja (2019). "Association of FOXA1 and EMT markers (Twist1 and E-cadherin) in breast cancer". Molecular Biology Reports (به انگلیسی). 46 (3): 3247–3255. doi:10.1007/s11033-019-04784-w. ISSN 0301-4851. PMID 30941644.

مشارکت‌کنندگان ویکی‌پدیا. «FOXA1». در دانشنامهٔ ویکی‌پدیای انگلیسی.

برای مطالعهٔ بیشتر

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Zhang Y, Ali TZ, Zhou H, et al. (2010). "ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer". Cancer Res. 70 (1): 240–8. doi:10.1158/0008-5472.CAN-09-2904. PMC 3724404. PMID 20048076.
McMullin RP, Dobi A, Mutton LN, et al. (2010). "A FOXA1-binding enhancer regulates Hoxb13 expression in the prostate gland". Proc. Natl. Acad. Sci. U.S.A. 107 (1): 98–103. doi:10.1073/pnas.0902001107. PMC 2806740. PMID 20018680.
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Haiman CA, Garcia RR, Hsu C, et al. (2009). "Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort". BMC Cancer. 9: 43. doi:10.1186/1471-2407-9-43. PMC 2637888. PMID 19183483.
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Malik S, Jiang S, Garee JP, et al. (2010). "Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM". Mol. Cell. Biol. 30 (2): 399–412. doi:10.1128/MCB.00907-09. PMC 2798473. PMID 19917725.
Motallebipour M, Ameur A, Reddy Bysani MS, et al. (2009). "Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq". Genome Biol. 10 (11): R129. doi:10.1186/gb-2009-10-11-r129. PMC 3091322. PMID 19919681.
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Iacobazzi V, Infantino V, Bisaccia F, et al. (2009). "Role of FOXA in mitochondrial citrate carrier gene expression and insulin secretion". Biochem. Biophys. Res. Commun. 385 (2): 220–4. doi:10.1016/j.bbrc.2009.05.030. PMID 19445897.
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پیوند به بیرون

FOXA1 در دانشنامهٔ اجزای دی‌ان‌ای

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000035451 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: forkhead box A1".

[pmid_8652662-5] Bingle CD, Gowan S (1996). "Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line". Biochim Biophys Acta. 1307 (1): 17–20. doi:10.1016/0167-4781(96)00058-9. PMID 8652662.

[pmid_9119385-6] Mincheva A, Lichter P, Schütz G, Kaestner KH (1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics. 39 (3): 417–9. doi:10.1006/geno.1996.4477. PMID 9119385.

[Barbieri_2012-7] Barbieri CE, Baca SC, Lawrence MS, Demichelis F, Blattner M, Theurillat JP, White TA, Stojanov P, Van Allen E, Stransky N, Nickerson E, Chae SS, Boysen G, Auclair D, Onofrio RC, Park K, Kitabayashi N, MacDonald TY, Sheikh K, Vuong T, Guiducci C, Cibulskis K, Sivachenko A, Carter SL, Saksena G, Voet D, Hussain WM, Ramos AH, Winckler W, Redman MC, Ardlie K, Tewari AK, Mosquera JM, Rupp N, Wild PJ, Moch H, Morrissey C, Nelson PS, Kantoff PW, Gabriel SB, Golub TR, Meyerson M, Lander ES, Getz G, Rubin MA, Garraway LA (June 2012). "Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer". Nat. Genet. 44 (6): 685–9. doi:10.1038/ng.2279. PMC 3673022. PMID 22610119.

[8] BenAyed-Guerfali, Dorra; Dabbèche-Bouricha, Emna; Ayadi, Wajdi; Trifa, Fatma; Charfi, Slim; Khabir, Abdelmajid; Sellami-Boudawara, Tahia; Mokdad-Gargouri, Raja (2019). "Association of FOXA1 and EMT markers (Twist1 and E-cadherin) in breast cancer". Molecular Biology Reports (به انگلیسی). 46 (3): 3247–3255. doi:10.1007/s11033-019-04784-w. ISSN 0301-4851. PMID 30941644.

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