"When Something Is Wrong with My Baby" is a 1967 song by soul duo Sam & Dave. It when to number 42 in the United States and was covered by Johnny Gill.
In 1991, Jimmy Barnes and John Farnham released a version of When Something Is Wrong with My Baby as the second single from Jimmy Barnes' fifth studio album Soul Deep. It went to number 3 in Australia and number 6 in New Zealand.