纳米鲁单抗 (INN :namilumab;开发代号:MT203 ),或译那美芦单抗 ,是一种人单克隆抗体 (IgG1 κ 类),靶向粒细胞-巨噬细胞集落刺激因子 (简称GM-CSF或CSF2),目前正在研究用于类风湿性关节炎 和银屑病关节炎 。[ 1] [ 2] [ 3] 纳米鲁单抗正在进行I期和II期临床试验,以确定该抗体在斑块型银屑病 [ 4] 和类风湿性关节炎中的安全性、耐受性和初步治疗效用。[ 5] [ 6]
纳米鲁单抗由武田制药 国际公司开发并由Micromet Inc生产。[ 3] [ 7]
^ World Health Organization . International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 104 (PDF) . WHO Drug Information. 2010, 24 (4). ^ Huizinga T, Batalov A, Stoilov R, Lloyd E, Wagner T, Saurigny D, Souberbielle B, Esfandiari E. Namilumab, an Anti-Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Monoclonal Antibody: Results of the First Study in Patients with Mild-to-Moderate Rheumatoid Arthritis (RA): Abstract Number: 969 . Arthritis & Rheumatology. October 2015, 67 . ^ 3.0 3.1 Namilumab . Adis Insight. Springer Nature Switzerland AG. [2017-03-24 ] . ^ Clinical trial number NCT02129777 for "Efficacy and Safety of Namilumab (MT203) for Plaque Psoriasis" at ClinicalTrials.gov ^ A 24-week Randomized, Open-Label, Parallel-Group, Active-Controlled, Exploratory, Proof-of-Mechanism Imaging Study Investigating the Efficacy of 150 mg of Namilumab Administered Subcutaneously vs Adalimumab in Patients With Moderate to Severe Early Rheumatoid Arthritis Inadequately Responding to Methotrexate . Adis Insight. Springer Nature Switzerland AG. [2017-03-24 ] . ^ Clinical trial number NCT02379091 for "Dose Finding Study of Namilumab in Combination With Methotrexate in Participants With Moderate to Severe Rheumatoid Arthritis (RA)" at ClinicalTrials.gov ^ Namilumab . Takeda clinical trials summary. 趋化因子受体 集落刺激因子 (CSF)
細胞因子受體
IFNAR (α/β, I) 激動劑: Albinterferon Interferon alpha (interferon alfa, IFN-α) Interferon alfa (IFNA1 , IFNA2 , IFNA4 , IFNA5 , IFNA6 , IFNA7 , IFNA8 , IFNA10 , IFNA13 , IFNA14 , IFNA16 , IFNA17 , IFNA21 ) Interferon alfa 2a Interferon alfa 2b Interferon alfa n1 Interferon alfacon-1 Interferon alpha-n3 Interferon beta (IFN-β) (IFNB1 , IFNB3 ) Interferon beta 1a Interferon beta 1b Interferon kappa (IFN-ε/κ/τ/ζ, IFNK) Interferon omega (IFN-ω, IFNW1) Peginterferon alfa-2a Peginterferon alfa-2b IFNGR (γ, II) IFNLR (λ, III)
白介素受體 TGFβ型受體 (TGFβ)TNF受體超家族 (TNFRSF)其它