MALAT1 - 维基百科，自由的百科全书

MALAT-1的二級結構
	预测的MALAT-1的二级结构和保守序列
识别符
代号	MALAT1
Rfam	RF01871
	其他数据
RNA类型	长链非编码RNA;
域	真核生物;

MALAT1
識別號
别名	MALAT1；, HCN, LINC00047, MALAT-1, NCRNA00047, NEAT2, PRO2853, mascRNA, metastasis associated lung adenocarcinoma transcript 1 (non-protein coding), metastasis associated lung adenocarcinoma transcript 1
外部ID	OMIM：607924 GeneCards：MALAT1
基因位置（人类）
染色体	11號染色體
终止	65,506,516 bp
直系同源
	378938
	无数据
	ENSG00000251562
	无数据
	无数据
	无数据
	无数据
	无数据
	无数据
	无数据
	維基數據
檢視/編輯人類

MALAT-1（英語：metastasis associated lung adenocarcinoma transcript 1的缩写，也称为NEAT2，noncoding nuclear-enriched abundant transcript 2）是一个长链非编码RNA 基因，表达于细胞核，在哺乳动物中高度保守^[3]。MALAT-1參與調控細胞核的組織、mRNA的選擇性剪接、DNA的表觀遺傳修飾等細胞中的多種反應，可控制參與腫瘤遠端轉移的基因表現^[4]。此RNA表現異常與糖尿病與癌症等多種疾病有關^[5]^[6]，其高表現和多種癌症較差的存活率呈正相關^[7]^[8]。

另见

NEAT1，也位于11号染色体上游处
MALAT1相关胞浆小RNA，mascRNA

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000251562 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hutchinson JN, Ensminger AW, Clemson CM, Lynch CR, Lawrence JB, Chess A. A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains. BMC Genomics. 2007, 8: 39. PMC 1800850 . PMID 17270048. doi:10.1186/1471-2164-8-39.
^ Gutschner T, Hämmerle M, Eissmann M, Hsu J, Kim Y, Hung G, Revenko A, Arun G, Stentrup M, Gross M, Zörnig M, MacLeod AR, Spector DL, Diederichs S. The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Research. February 2013, 73 (3): 1180–1189. PMC 3589741 . PMID 23243023. doi:10.1158/0008-5472.CAN-12-2850.
^ Wu Y, Huang C, Meng X, Li J. Long Noncoding RNA MALAT1: Insights into its Biogenesis and Implications in Human Disease. Current Pharmaceutical Design. 2015, 21 (34): 5017–5028. PMID 26205289. doi:10.2174/1381612821666150724115625.
^ Yoshimoto R, Mayeda A, Yoshida M, Nakagawa S. MALAT1 long non-coding RNA in cancer. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. January 2016, 1859 (1): 192–199. PMID 26434412. doi:10.1016/j.bbagrm.2015.09.012.
^ Tian X, Xu G. Clinical value of lncRNA MALAT1 as a prognostic marker in human cancer: systematic review and meta-analysis. BMJ Open. 2015, 5 (9): e008653. PMC 4593150 . PMID 26423854. doi:10.1136/bmjopen-2015-008653.
^ Wei Y, Niu B. Role of MALAT1 as a Prognostic Factor for Survival in Various Cancers: A Systematic Review of the Literature with Meta-Analysis. Disease Markers. 2015, 2015: 164635. PMC 4572489 . PMID 26420912. doi:10.1155/2015/164635 .

外部链接

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000251562 - Ensembl, May 2017

[2] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid17270048-3] Hutchinson JN, Ensminger AW, Clemson CM, Lynch CR, Lawrence JB, Chess A. A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains. BMC Genomics. 2007, 8: 39. PMC 1800850 . PMID 17270048. doi:10.1186/1471-2164-8-39.

[4] Gutschner T, Hämmerle M, Eissmann M, Hsu J, Kim Y, Hung G, Revenko A, Arun G, Stentrup M, Gross M, Zörnig M, MacLeod AR, Spector DL, Diederichs S. The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Research. February 2013, 73 (3): 1180–1189. PMC 3589741 . PMID 23243023. doi:10.1158/0008-5472.CAN-12-2850.

[5] Wu Y, Huang C, Meng X, Li J. Long Noncoding RNA MALAT1: Insights into its Biogenesis and Implications in Human Disease. Current Pharmaceutical Design. 2015, 21 (34): 5017–5028. PMID 26205289. doi:10.2174/1381612821666150724115625.

[Yoshimoto-6] Yoshimoto R, Mayeda A, Yoshida M, Nakagawa S. MALAT1 long non-coding RNA in cancer. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. January 2016, 1859 (1): 192–199. PMID 26434412. doi:10.1016/j.bbagrm.2015.09.012.

[7] Tian X, Xu G. Clinical value of lncRNA MALAT1 as a prognostic marker in human cancer: systematic review and meta-analysis. BMJ Open. 2015, 5 (9): e008653. PMC 4593150 . PMID 26423854. doi:10.1136/bmjopen-2015-008653.

[8] Wei Y, Niu B. Role of MALAT1 as a Prognostic Factor for Survival in Various Cancers: A Systematic Review of the Literature with Meta-Analysis. Disease Markers. 2015, 2015: 164635. PMC 4572489 . PMID 26420912. doi:10.1155/2015/164635 .

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