نيتازوكسانيد - ويكيبيديا

نيتازوكسانيد
يعالج	داء خفيات الأبواغ، وداء الجيارديات
اعتبارات علاجية
معرّفات
CAS	55981-09-4
ك ع ت	P01AX11
بوب كيم	41684
ECHA InfoCard ID	100.054.465
درغ بنك	DB00507
كيم سبايدر	38037
المكون الفريد	SOA12P041N
كيوتو	D02486
ChEMBL	CHEMBL1401
بيانات كيميائية
الصيغة الكيميائية	C₁₂H₉N₃O₅S
	محددات الإدخال الخطي النصي الجزيئي المبسط
	المعرف الكيميائي الدولي
	تعديل مصدري - تعديل

نيتازوكسانيد (بالإنجليزية: Nitazoxanide)‏ هو دواء يُستعمل في علاج:^[6]^[7]^[8]

دوره

يلعب هذا الدواء دورًا في علاج الأمراض كونه:^[10]

المراجع

^ ^ا ^ب Lyne Jossé; Anastasios D Tsaousis (3 Dec 2018). "Past and future trends of Cryptosporidium in vitro research". Experimental Parasitology (بالإنجليزية). 196: 28–37. DOI:10.1016/J.EXPPARA.2018.12.001. ISSN:0014-4894. PMC:6333944. PMID:30521793. QID:Q60922614.
^ ^ا ^ب ^ج ^د NITAZOXANIDE (بالإنجليزية), QID:Q278487
^ Nitazoxanide، QID:Q2311683
^ Nitazoxanide، QID:Q6120337
^ NITAZOXANIDE، QID:Q6120337
^ Rossignol JF (أكتوبر 2014). "Nitazoxanide: a first-in-class broad-spectrum antiviral agent". Antiviral Res. ج. 110: 94–103. DOI:10.1016/j.antiviral.2014.07.014. PMID:25108173. Originally developed and commercialized as an antiprotozoal agent, nitazoxanide was later identified as a first-in-class broad-spectrum antiviral drug and has been repurposed for the treatment of influenza. ... From a chemical perspective, nitazoxanide is the scaffold for a new class of drugs called thiazolides. These small-molecule drugs target host-regulated processes involved in viral replication. ... A new dosage formulation of nitazoxanide is presently undergoing global Phase 3 clinical development for the treatment of influenza. Nitazoxanide inhibits a broad range of influenza A and B viruses including influenza A(pH1N1) and the avian A(H7N9) as well as viruses that are resistant to neuraminidase inhibitors. ... Nitazoxanide also inhibits the replication of a broad range of other RNA and DNA viruses including respiratory syncytial virus, parainfluenza, coronavirus, rotavirus, norovirus, hepatitis B, hepatitis C, dengue, yellow fever, Japanese encephalitis virus and human immunodeficiency virus in cell culture assays. Clinical trials have indicated a potential role for thiazolides in treating rotavirus and norovirus gastroenteritis and chronic hepatitis B and chronic hepatitis C. Ongoing and future clinical development is focused on viral respiratory infections, viral gastroenteritis and emerging infections such as dengue fever.
^ Di Santo N، Ehrisman J (2013). "Research perspective: potential role of nitazoxanide in ovarian cancer treatment. Old drug, new purpose?". Cancers (Basel). ج. 5 ع. 3: 1163–1176. DOI:10.3390/cancers5031163. PMC:3795384. PMID:24202339. Nitazoxanide [NTZ: 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide] is a thiazolide antiparasitic agent with excellent activity against a wide variety of protozoa and helminths. ... Nitazoxanide (NTZ) is a main compound of a class of broad-spectrum anti-parasitic compounds named thiazolides. It is composed of a nitrothiazole-ring and a salicylic acid moiety which are linked together by an amide bond ... NTZ is generally well tolerated, and no significant adverse events have been noted in human trials [13]. ... In vitro, NTZ and tizoxanide function against a wide range of organisms, including the protozoal species Blastocystis hominis, C. parvum, Entamoeba histolytica, G. lamblia and Trichomonas vaginalis [13]{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)
^ White CA (2004). "Nitazoxanide: a new broad spectrum antiparasitic agent". Expert Rev Anti Infect Ther. ج. 2 ع. 1: 43–9. DOI:10.1586/14787210.2.1.43. PMID:15482170.
^ ^ا ^ب "معرف المصطلحات المرجعية بملف المخدرات الوطني". المصطلحات المرجعية بملف العقاقير الوطني. مؤرشف من الأصل في 2019-05-30. اطلع عليه بتاريخ 2016-12-13.
^ "معرف المصطلحات المرجعية بملف المخدرات الوطني". المصطلحات المرجعية بملف العقاقير الوطني. مؤرشف من الأصل في 2019-05-30. اطلع عليه بتاريخ 2018-03-05.

إخلاء مسؤولية طبية

هذه بذرة مقالة عن الصيدلة بحاجة للتوسيع. فضلًا شارك في تحريرها.

[wikidata-19166867a096691c8a1beeb738d6b1aeea4b76db-1] ا ^ب Lyne Jossé; Anastasios D Tsaousis (3 Dec 2018). "Past and future trends of Cryptosporidium in vitro research". Experimental Parasitology (بالإنجليزية). 196: 28–37. DOI:10.1016/J.EXPPARA.2018.12.001. ISSN:0014-4894. PMC:6333944. PMID:30521793. QID:Q60922614.

[wikidata-1fb9e65d5494238ec742f26a8186f39e60fb81e0-2] ا ^ب ^ج ^د NITAZOXANIDE (بالإنجليزية), QID:Q278487

[wikidata-bb7469d3d987a9d379b19819d8eca0a8a1f53e4e-3] Nitazoxanide، QID:Q2311683

[wikidata-ab5fdb7a841c53bbe2452817d55ed6e5a7e7fd73-4] Nitazoxanide، QID:Q6120337

[wikidata-8a54380bc814e9e71474291e550fdcd1e3c02f4d-5] NITAZOXANIDE، QID:Q6120337

[Broad-spectrum_antiviral_review-6] Rossignol JF (أكتوبر 2014). "Nitazoxanide: a first-in-class broad-spectrum antiviral agent". Antiviral Res. ج. 110: 94–103. DOI:10.1016/j.antiviral.2014.07.014. PMID:25108173. Originally developed and commercialized as an antiprotozoal agent, nitazoxanide was later identified as a first-in-class broad-spectrum antiviral drug and has been repurposed for the treatment of influenza. ... From a chemical perspective, nitazoxanide is the scaffold for a new class of drugs called thiazolides. These small-molecule drugs target host-regulated processes involved in viral replication. ... A new dosage formulation of nitazoxanide is presently undergoing global Phase 3 clinical development for the treatment of influenza. Nitazoxanide inhibits a broad range of influenza A and B viruses including influenza A(pH1N1) and the avian A(H7N9) as well as viruses that are resistant to neuraminidase inhibitors. ... Nitazoxanide also inhibits the replication of a broad range of other RNA and DNA viruses including respiratory syncytial virus, parainfluenza, coronavirus, rotavirus, norovirus, hepatitis B, hepatitis C, dengue, yellow fever, Japanese encephalitis virus and human immunodeficiency virus in cell culture assays. Clinical trials have indicated a potential role for thiazolides in treating rotavirus and norovirus gastroenteritis and chronic hepatitis B and chronic hepatitis C. Ongoing and future clinical development is focused on viral respiratory infections, viral gastroenteritis and emerging infections such as dengue fever.

[Thiazolides-7] Di Santo N، Ehrisman J (2013). "Research perspective: potential role of nitazoxanide in ovarian cancer treatment. Old drug, new purpose?". Cancers (Basel). ج. 5 ع. 3: 1163–1176. DOI:10.3390/cancers5031163. PMC:3795384. PMID:24202339. Nitazoxanide [NTZ: 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide] is a thiazolide antiparasitic agent with excellent activity against a wide variety of protozoa and helminths. ... Nitazoxanide (NTZ) is a main compound of a class of broad-spectrum anti-parasitic compounds named thiazolides. It is composed of a nitrothiazole-ring and a salicylic acid moiety which are linked together by an amide bond ... NTZ is generally well tolerated, and no significant adverse events have been noted in human trials [13]. ... In vitro, NTZ and tizoxanide function against a wide range of organisms, including the protozoal species Blastocystis hominis, C. parvum, Entamoeba histolytica, G. lamblia and Trichomonas vaginalis [13]{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)

[Nitazoxanide:_Broad-spectrum_antiparasitic-8] White CA (2004). "Nitazoxanide: a new broad spectrum antiparasitic agent". Expert Rev Anti Infect Ther. ج. 2 ع. 1: 43–9. DOI:10.1586/14787210.2.1.43. PMID:15482170.

[مولد_تلقائيا1-9] ا ^ب "معرف المصطلحات المرجعية بملف المخدرات الوطني". المصطلحات المرجعية بملف العقاقير الوطني. مؤرشف من الأصل في 2019-05-30. اطلع عليه بتاريخ 2016-12-13.

[10] "معرف المصطلحات المرجعية بملف المخدرات الوطني". المصطلحات المرجعية بملف العقاقير الوطني. مؤرشف من الأصل في 2019-05-30. اطلع عليه بتاريخ 2018-03-05.

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نيتازوكسانيد

يعالج	داء خفيات الأبواغ^[1]، وداء الجيارديات^[1]
اعتبارات علاجية


معرّفات
CAS	55981-09-4
ك ع ت	P01AX11
بوب كيم	41684^[2]
ECHA InfoCard ID	100.054.465
درغ بنك	DB00507
كيم سبايدر	38037^[3]
المكون الفريد	SOA12P041N
كيوتو	D02486^[4]
ChEMBL	CHEMBL1401^[5]
بيانات كيميائية
الصيغة الكيميائية	C₁₂H₉N₃O₅S^[2]
محددات الإدخال الخطي النصي الجزيئي المبسط CC(=O)OC1=CC=CC=C1C(=O)NC2=NC=C(S2)[N+](=O)[O-]^[2]
المعرف الكيميائي الدولي InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)^[2]

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