60S ribosomal protein L15

RPL15
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UG0, 4V6X, 5AJ0, 3J7R, 4V5Z, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 3J7Q, 4UJE, 3J7O, 4UJC,%%s3J7R, 4V5Z, 4V6X, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 5AJ0, 3J7Q, 4UG0, 4UJE, 3J7O, 4UJC
Identifiers
Aliases	RPL15, DBA12, EC45, L15, RPL10, RPLY10, RPYL10, ribosomal protein L15
External IDs	OMIM: 604174; MGI: 1913730; HomoloGene: 37713; GeneCards: RPL15; OMA:RPL15 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	23,924,374 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	4,201,873 bp
RNA expression pattern
	Top expressed in
	left ovary; ; left testis; ; right testis; ; right ovary; ; germinal epithelium; ; middle temporal gyrus; ; gonad; ; gallbladder; ; canal of the cervix; ; caput epididymis;
	Top expressed in
	embryo; ; ventricular zone; ; embryo; ; morula; ; blastocyst; ; epiblast; ; yolk sac; ; primitive streak; ; lip; ; Gonadal ridge;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; structural constituent of ribosome; cadherin binding; RNA binding;
Cellular component	cytosol; ribosome; membrane; intracellular anatomical structure; extracellular exosome; nucleus; cytosolic large ribosomal subunit; A band;
Biological process	cytoplasmic translation; protein biosynthesis; viral transcription; SRP-dependent cotranslational protein targeting to membrane; translational initiation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; rRNA processing; response to ethanol;
	Sources:Amigo / QuickGO
Orthologs
	6138
	66480
	ENSG00000174748
	ENSMUSG00000012405
	P61313
	Q9CZM2
NM_001253379; NM_001253380; NM_001253382; NM_001253383; NM_001253384;
	NM_002948
	NM_025586; NM_001359897; NM_001359899
NP_001240308; NP_001240309; NP_001240311; NP_001240312; NP_001240313;
	NP_002939; NP_001240308.1; NP_001240309.1; NP_001240311.1; NP_001240312.1; NP_002939.2
	NP_079862; NP_001346826; NP_001346828
	Wikidata
View/Edit Human	View/Edit Mouse

60S ribosomal protein L15 is a protein that in humans is encoded by the RPL15 gene.^[5]^[6]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15E family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Although this gene has been referred to as RPL10, its official symbol is RPL15. This gene has been shown to be overexpressed in some esophageal tumors compared to normal matched tissues. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174748 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000012405 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
^ ^a ^b "Entrez Gene: RPL15 ribosomal protein L15".

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Adams MD, Dubnick M, Kerlavage AR, et al. (1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. Bibcode:1992Natur.355..632A. doi:10.1038/355632a0. PMID 1538749. S2CID 4234345.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Wang Q, Yang C, Zhou J, et al. (2001). "Cloning and characterization of full-length human ribosomal protein L15 cDNA which was overexpressed in esophageal cancer". Gene. 263 (1–2): 205–9. doi:10.1016/S0378-1119(00)00570-9. PMID 11223259.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Wang H, Zhao LN, Li KZ, et al. (2006). "Overexpression of ribosomal protein L15 is associated with cell proliferation in gastric cancer". BMC Cancer. 6: 91. doi:10.1186/1471-2407-6-91. PMC 1459873. PMID 16608517.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174748 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000012405 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9582194-5] Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.

[entrez-6] "Entrez Gene: RPL15 ribosomal protein L15".

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[5]

[6]

60S ribosomal protein L15

References

Further reading