AR-231,453

AR-231,453
Identifiers
  • N-(2-fluoro-4-methanesulfonylphenyl)-(6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-5-nitropyrimidin-4-yl)amine
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC21H24FN7O5S
Molar mass505.53 g·mol−1
3D model (JSmol)
  • Fc2cc(S(=O)(C)=O)ccc2Nc1ncnc(c1N(=O)=O)N(CC3)CCC3c(n4)onc4C(C)C
  • InChI=1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-16-5-4-14(10-15(16)22)35(3,32)33/h4-5,10-13H,6-9H2,1-3H3,(H,23,24,25) checkY
  • Key:DGBKNTVAKIFYNU-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

AR-231,453 is an agonist for the suggested novel cannabinoid receptor GPR119.[1]

See also

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References

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  1. ^ Semple G, Fioravanti B, Pereira G, Calderon I, Uy J, Choi K, Xiong Y, Ren A, Morgan M, Dave V, Thomsen W, Unett DJ, Xing C, Bossie S, Carroll C, Chu ZL, Grottick AJ, Hauser EK, Leonard J, Jones RM (2008). "Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119". J Med Chem. 51 (17): 5172–5175. doi:10.1021/jm8006867. PMID 18698756.