Acetoacetate—CoA ligase
Acetoacetate—CoA ligase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC no. | 6.2.1.16 | ||||||||
CAS no. | 39394-62-2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
|
In enzymology, an acetoacetate—CoA ligase (EC 6.2.1.16) is an enzyme that catalyzes the chemical reaction
- ATP + acetoacetate + CoA AMP + diphosphate + acetoacetyl-CoA
The 3 substrates of this enzyme are ATP, acetoacetate, and CoA, whereas its 3 products are AMP, diphosphate, and acetoacetyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is acetoacetate:CoA ligase (AMP-forming). This enzyme is also called acetoacetyl-CoA synthetase. This enzyme participates in butanoate metabolism.
References
[edit]- Fukui T, Ito M, Tomita K (1982). "Purification and characterization of acetoacetyl-CoA synthetase from Zoogloea ramigera I-16-M". Eur. J. Biochem. 127 (2): 423–8. doi:10.1111/j.1432-1033.1982.tb06889.x. PMID 7140777.