CDK12

CDK12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CXA, 4NST, 4UN0, 5ACB
Identifiers
Aliases	CDK12, CRK7, CRKR, CRKRS, cyclin-dependent kinase 12, cyclin dependent kinase 12
External IDs	OMIM: 615514; MGI: 1098802; HomoloGene: 128632; GeneCards: CDK12; OMA:CDK12 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	39,564,907 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,169,330 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; sural nerve; ; secondary oocyte; ; epithelium of colon; ; ganglionic eminence; ; gastric mucosa; ; ventricular zone; ; Achilles tendon; ; skin of leg; ; tonsil;
	Top expressed in
	zygote; ; secondary oocyte; ; ascending aorta; ; tail of embryo; ; Rostral migratory stream; ; aortic valve; ; genital tubercle; ; granulocyte; ; spermatocyte; ; primary oocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; protein serine/threonine kinase activity; protein binding; RNA polymerase II CTD heptapeptide repeat kinase activity; ATP binding; cyclin binding; cyclin-dependent protein serine/threonine kinase activity; transcription factor binding; protein kinase binding;
Cellular component	nuclear speck; nuclear cyclin-dependent protein kinase holoenzyme complex; cyclin K-CDK12 complex; nucleus; nucleoplasm; fibrillar center; chromosome; cyclin/CDK positive transcription elongation factor complex; cyclin-dependent protein kinase holoenzyme complex;
Biological process	phosphorylation of RNA polymerase II C-terminal domain; phosphorylation; mRNA processing; regulation of cell cycle; protein phosphorylation; regulation of RNA splicing; RNA splicing; protein autophosphorylation; regulation of MAP kinase activity; transcription elongation from RNA polymerase II promoter; positive regulation of transcription by RNA polymerase II; negative regulation of stem cell differentiation; positive regulation of transcription elongation from RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	51755
	69131
	ENSG00000167258
	ENSMUSG00000003119
	Q9NYV4
	Q14AX6
	NM_015083; NM_016507
	NM_001109626; NM_001109628; NM_026952
	NP_055898; NP_057591
	NP_001103096; NP_001103098; NP_081228
	Wikidata
View/Edit Human	View/Edit Mouse

CDK12 cyclin-dependent kinase 12 is a protein kinase that in humans is encoded by the CDK12 gene.^[5]^[6]^[7] This enzyme is a member of cyclin-dependent kinase protein family.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167258 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003119 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
^ Ko TK, Kelly E, Pines J (Oct 2001). "CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles". J Cell Sci. 114 (Pt 14): 2591–603. doi:10.1242/jcs.114.14.2591. PMID 11683387.
^ "Entrez Gene: CDK12 cyclin-dependent kinase 12".

External links

Human CDK12 genome location and CDK12 gene details page in the UCSC Genome Browser.

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry" (PDF). Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257. S2CID 40974821.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167258 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003119 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10048485-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.

[pmid11683387-6] Ko TK, Kelly E, Pines J (Oct 2001). "CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles". J Cell Sci. 114 (Pt 14): 2591–603. doi:10.1242/jcs.114.14.2591. PMID 11683387.

[entrez-7] "Entrez Gene: CDK12 cyclin-dependent kinase 12".

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[3]

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[5]

[6]

[7]

CDK12

References

External links

Further reading