ε-Amanitin
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Identifiers | |
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3D model (JSmol) | |
ChemSpider | |
PubChem CID | |
CompTox Dashboard (EPA) | |
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Properties | |
C39H53N9O14S | |
Molar mass | 903.96 g/mol |
Appearance | Colorless, crystalline solid |
Soluble | |
Solubility in ethanol and methanol | Soluble |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
ε-Amanitin (epsilon-Amanitin) is a cyclic peptide. It is an amatoxin, all of which are found in several members of the mushroom genus Amanita. The oral LD50 of ε-amanitin is approximately 0.1 mg/kg.
Toxicology
[edit]Like other amatoxins, ε-amanitin is an inhibitor of RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme which completely prevents mRNA synthesis, effectively causing cytolysis of hepatocytes (liver cells) and kidney cells.[1]
See also
[edit]References
[edit]- ^ M. Cochet-Meillhac; Chambon P. (1974). "Animal DNA-dependent RNA polymerases. 11. Mechanism of the inhibition of RNA polymerases B by amatoxins". Biochim Biophys Acta. 353 (2): 160–184. doi:10.1016/0005-2787(74)90182-8. PMID 4601749.
External links
[edit]- Amatoxins REVISED Archived 2009-01-13 at the Wayback Machine
- Poisonous Mushrooms (German)