Protein-coding gene in the species Homo sapiens
Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene .[ 5] [ 6]
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for type I interferons , including interferon-alpha, -beta, and -lambda. Binding and activation of the receptor stimulates Janus protein kinases , which in turn phosphorylate several proteins, including STAT1 and STAT2 . The encoded protein also functions as an antiviral factor.[ 6]
IFNAR1 has been shown to interact with:
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"Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling" . Mol. Cell. Biol . 17 (4): 2048–56. doi :10.1128/mcb.17.4.2048 . PMC 232052 PMID 9121453 . ^ Uddin S, Chamdin A, Platanias LC (Oct 1995). "Interaction of the transcriptional activator Stat-2 with the type I interferon receptor" . J. Biol. Chem . 270 (42): 24627–30. doi :10.1074/jbc.270.42.24627 PMID 7559568 . ^ Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JT, Schreiber RD, Schindler CW, Krolewski JJ (Mar 1996). "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein" . EMBO J . 15 (5): 1064–74. doi :10.1002/j.1460-2075.1996.tb00444.x . PMC 450004 PMID 8605876 . ^ Richter MF, Duménil G, Uzé G, Fellous M, Pellegrini S (Sep 1998). "Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1" . J. Biol. 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