OR2B6

OR2B6
Identifiers
Aliases	OR2B6, OR2B1, OR2B1P, OR2B5, OR2B6P, OR5-40, OR5-41, OR6-31, dJ408B20.2, olfactory receptor family 2 subfamily B member 6
External IDs	MGI: 104715; HomoloGene: 40838; GeneCards: OR2B6; OMA:OR2B6 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	27,958,182 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	21,826,688 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; monocyte; ; gonad; ; blood; ; granulocyte; ; right lobe of liver; ; placenta; ; spleen; ; Ventricular system of neuraxis; ; embryo;
	Top expressed in
	white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; olfactory receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	sensory perception of smell; signal transduction; response to stimulus; detection of chemical stimulus involved in sensory perception of smell; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	26212
	218066
	ENSG00000124657
	ENSMUSG00000036658
	P58173
	Q60890
	NM_012367
	NM_146542
	NP_036499
	NP_666753
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 2B6 is a protein that in humans is encoded by the OR2B6 gene.^[5]^[6]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124657 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036658 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D (Mar 1998). "Distribution of olfactory receptor genes in the human genome". Nat Genet. 18 (3): 243–50. doi:10.1038/ng0398-243. PMID 9500546. S2CID 31129045.
^ ^a ^b "Entrez Gene: OR2B6 olfactory receptor, family 2, subfamily B, member 6".

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124657 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036658 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9500546-5] Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D (Mar 1998). "Distribution of olfactory receptor genes in the human genome". Nat Genet. 18 (3): 243–50. doi:10.1038/ng0398-243. PMID 9500546. S2CID 31129045.

[entrez-6] "Entrez Gene: OR2B6 olfactory receptor, family 2, subfamily B, member 6".

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OR2B6

See also

References

Further reading