Rap GTP-binding protein

RAP1B,
member of RAS oncogene family
RAP1B,; member of RAS oncogene family
Identifiers
Symbol	RAP1B
NCBI gene	5908
HGNC	9857
OMIM	179530
RefSeq	NM_015646
UniProt	P61224
Other data
Locus	Chr. 12 q14
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Search for
Structures	Swiss-model
Domains	InterPro

RAP1A,
member of RAS oncogene family
RAP1A,; member of RAS oncogene family
Identifiers
Symbol	RAP1A
NCBI gene	5906
HGNC	9855
OMIM	179520
RefSeq	NM_002884
UniProt	P62834
Other data
Locus	Chr. 1 p13.3
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Rap GTP-binding protein also known as Ras-related proteins or simply RAP is a type of small GTPase, similar in structure to Ras.

These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. RAP counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner.^[1]^[2]

Family members

Human genes that encode Ras-related proteins include:

References

^ "RAP1A RAP1A, member of RAS oncogene family". Entrez Gene. United States National Library of Medicine.
^ Rousseau-Merck MF, Pizon V, Tavitian A, Berger R (1990). "Chromosome mapping of the human RAS-related RAP1A, RAP1B, and RAP2 genes to chromosomes 1p12----p13, 12q14, and 13q34, respectively". Cytogenet. Cell Genet. 53 (1): 2–4. doi:10.1159/000132883. PMID 2108841.

External links

rap+GTP-Binding+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[url_RAP1A-1] "RAP1A RAP1A, member of RAS oncogene family". Entrez Gene. United States National Library of Medicine.

[pmid2108841-2] Rousseau-Merck MF, Pizon V, Tavitian A, Berger R (1990). "Chromosome mapping of the human RAS-related RAP1A, RAP1B, and RAP2 genes to chromosomes 1p12----p13, 12q14, and 13q34, respectively". Cytogenet. Cell Genet. 53 (1): 2–4. doi:10.1159/000132883. PMID 2108841.

[1]

[2]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)