Protein-coding gene in the species Homo sapiens
Phospholipid-transporting ATPase VA also known as ATPase class V type 10A or aminophospholipid translocase VA is an enzyme that in humans is encoded by the ATP10A gene .[ 5] [ 6] [ 7]
The protein encoded by ATP10A belongs to the family of P-type cation transport ATPases , and to the subfamily of aminophospholipid-transporting ATPases . The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene is maternally expressed. It maps within the most common interval of deletion responsible for Angelman syndrome , also known as 'happy puppet syndrome'.[ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000206190 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025324 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Halleck MS, Lawler JF JR, Blackshaw S, Gao L, Nagarajan P, Hacker C, Pyle S, Newman JT, Nakanishi Y, Ando H, Weinstock D, Williamson P, Schlegel RA (Oct 2000). "Differential expression of putative transbilayer amphipath transporters". Physiol Genomics . 1 (3): 139– 50. doi :10.1152/physiolgenomics.1999.1.3.139 . PMID 11015572 . S2CID 762447 . ^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" . DNA Res . 5 (1): 31– 9. doi :10.1093/dnares/5.1.31 PMID 9628581 . ^ "ATP10A - Phospholipid-transporting ATPase VA - Homo sapiens (Human) - ATP10A gene & protein" . www.uniprot.org . Retrieved 9 April 2022 .^ "Entrez Gene: ATP10A ATPase, Class V, type 10A" . Kato C, Tochigi M, Ohashi J, et al. (2008). "Association study of the 15q11-q13 maternal expression domain in Japanese autistic patients". American Journal of Medical Genetics . 147B (7): 1008– 12. doi :10.1002/ajmg.b.30690 . PMID 18186074 . S2CID 25223093 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proceedings of the National Academy of Sciences of the United States of America . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Dhar M, Hauser L, Johnson D (2003). "An aminophospholipid translocase associated with body fat and type 2 diabetes phenotypes" . Obes. Res . 10 (7): 695– 702. doi :10.1038/oby.2002.94 PMID 12105293 . Herzing LB, Kim SJ, Cook EH, Ledbetter DH (2001). "The Human Aminophospholipid-Transporting ATPase Gene ATP10C Maps Adjacent to UBE3A and Exhibits Similar Imprinted Expression" . Am. J. Hum. Genet . 68 (6): 1501– 5. doi :10.1086/320616 . PMC 1226137 PMID 11353404 . Meguro M, Kashiwagi A, Mitsuya K, et al. (2001). "A novel maternally expressed gene, ATP10C, encodes a putative aminophospholipid translocase associated with Angelman syndrome". Nat. Genet . 28 (1): 19– 20. doi :10.1038/88209 . PMID 11326269 . Gillessen-Kaesbach G, Demuth S, Thiele H, et al. (1999). "A previously unrecognised phenotype characterised by obesity, muscular hypotonia, and ability to speak in patients with Angelman syndrome caused by an imprinting defect" . European Journal of Human Genetics . 7 (6): 638– 44. doi :10.1038/sj.ejhg.5200362 PMID 10482951 .
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