Protein-coding gene in the species Homo sapiens
Gem-associated protein 2 (GEMIN2 ), also called survival of motor neuron protein-interacting protein 1 (SIP1 ), is a protein that in humans is encoded by the GEMIN2 gene .[ 5] [ 6] [ 7]
Gem-associated protein 2 has been shown to interact with DDX20 [ 8] [ 9] SMN1 .[ 6] [ 10]
^ a b c GRCh38: Ensembl release 89: ENSG00000092208 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060121 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Fischer U, Liu Q, Dreyfuss G (September 1997). "The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis" . Cell . 90 (6): 1023–1029. doi :10.1016/S0092-8674(00)80368-2 PMID 9323130 . ^ a b Liu Q, Fischer U, Wang F, Dreyfuss G (September 1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins" . Cell . 90 (6): 1013–1021. doi :10.1016/S0092-8674(00)80367-0 PMID 9323129 . ^ "Entrez Gene: SIP1 survival of motor neuron protein interacting protein 1" .^ Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, et al. (March 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs" . Genes & Development . 16 (6): 720–728. doi :10.1101/gad.974702 . PMC 155365 PMID 11914277 . ^ Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems" . The Journal of Cell Biology . 147 (6): 1181–1194. doi :10.1083/jcb.147.6.1181 . PMC 2168095 PMID 10601333 . ^ Meister G, Bühler D, Laggerbauer B, Zobawa M, Lottspeich F, Fischer U (August 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins" . Human Molecular Genetics . 9 (13): 1977–1986. doi :10.1093/hmg/9.13.1977 PMID 10942426 . Wang Z, Wu X, Friedberg EC (September 1997). "Molecular mechanism of base excision repair of uracil-containing DNA in yeast cell-free extracts" . The Journal of Biological Chemistry . 272 (38): 24064–24071. doi :10.1074/jbc.272.38.24064 PMID 9295360 . Zhang WJ, Wu JY (February 1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing" . Molecular and Cellular Biology . 18 (2): 676–684. doi :10.1128/mcb.18.2.676 . PMC 108778 PMID 9447963 . Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems" . The Journal of Cell Biology . 147 (6): 1181–1194. doi :10.1083/jcb.147.6.1181 . PMC 2168095 PMID 10601333 . Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (March 2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli" . The Journal of Cell Biology . 148 (6): 1177–1186. doi :10.1083/jcb.148.6.1177 . PMC 2174312 PMID 10725331 . Helmken C, Wetter A, Rudnik-Schöneborn S, Liehr T, Zerres K, Wirth B (July 2000). "An essential SMN interacting protein (SIP1) is not involved in the phenotypic variability of spinal muscular atrophy (SMA)" . European Journal of Human Genetics . 8 (7): 493–499. doi :10.1038/sj.ejhg.5200479 PMID 10909848 . Meister G, Bühler D, Laggerbauer B, Zobawa M, Lottspeich F, Fischer U (August 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins" . Human Molecular Genetics . 9 (13): 1977–1986. doi :10.1093/hmg/9.13.1977 PMID 10942426 . Young PJ, Man NT, Lorson CL, Le TT, Androphy EJ, Burghes AH, Morris GE (November 2000). "The exon 2b region of the spinal muscular atrophy protein, SMN, is involved in self-association and SIP1 binding" . Human Molecular Genetics . 9 (19): 2869–2877. doi :10.1093/hmg/9.19.2869 PMID 11092763 . Pellizzoni L, Charroux B, Rappsilber J, Mann M, Dreyfuss G (January 2001). "A functional interaction between the survival motor neuron complex and RNA polymerase II" . The Journal of Cell Biology . 152 (1): 75–85. doi :10.1083/jcb.152.1.75 . PMC 2193649 PMID 11149922 . Jablonka S, Bandilla M, Wiese S, Bühler D, Wirth B, Sendtner M, Fischer U (March 2001). "Co-regulation of survival of motor neuron (SMN) protein and its interactor SIP1 during development and in spinal muscular atrophy" . Human Molecular Genetics . 10 (5): 497–505. doi :10.1093/hmg/10.5.497 PMID 11181573 . Friesen WJ, Massenet S, Paushkin S, Wyce A, Dreyfuss G (May 2001). "SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets" . Molecular Cell . 7 (5): 1111–1117. doi :10.1016/S1097-2765(01)00244-1 PMID 11389857 . Park JW, Voss PG, Grabski S, Wang JL, Patterson RJ (September 2001). "Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein" . Nucleic Acids Research . 29 (17): 3595–3602. doi :10.1093/nar/29.17.3595 . PMC 55878 PMID 11522829 . Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, et al. (December 2001). "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins" . Molecular and Cellular Biology . 21 (24): 8289–8300. doi :10.1128/MCB.21.24.8289-8300.2001 . PMC 99994 PMID 11713266 . Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (February 2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins" . The Journal of Biological Chemistry . 277 (7): 5631–5636. doi :10.1074/jbc.M109448200 PMID 11714716 . Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (March 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component" . The Journal of Biological Chemistry . 277 (9): 7540–7545. doi :10.1074/jbc.M110141200 PMID 11748230 . Aerbajinai W, Ishihara T, Arahata K, Tsukahara T (June 2002). "Increased expression level of the splicing variant of SIP1 in motor neuron diseases". The International Journal of Biochemistry & Cell Biology . 34 (6): 699–707. doi :10.1016/S1357-2725(01)00150-9 . PMID 11943600 . Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (August 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex" . The Journal of Biological Chemistry . 277 (35): 31957–31962. doi :10.1074/jbc.M203478200 PMID 12065586 .
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