Protein-coding gene in humans
β-Mannosidase (EC 3.2.1.25 }, mannanase , mannase , β-D -mannosidase , β-mannoside mannohydrolase , exo-β-D -mannanase , lysosomal β A mannosidase ) is an enzyme with systematic name β-D -mannoside mannohydrolase , which is in humans encoded by the MANBA gene .[ 5] [ 6] [ 7] [ 8] [ 9] [ 10] catalyses the following chemical reaction
Hydrolysis of terminal, non-reducing β-D -mannose residues in β-D -mannosides This gene encodes a member of the glycosyl hydrolase 2 family . The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N -linked glycoproteinoligosaccharide catabolism. Mutations in this gene are associated with β-mannosidosis , a lysosomal storage disease that has a wide spectrum of neurological involvement.[ 5]
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Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Papandreou MJ, Fenouillet E (1997). "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation" . FEBS Lett . 406 (1–2): 191–5. doi :10.1016/S0014-5793(97)00273-1 PMID 9109416 . S2CID 17660 . Gao J, Arbman G, He L, et al. (2008). "MANBA polymorphism was related to increased risk of colorectal cancer in Swedish but not in Chinese populations". Acta Oncol . 47 (3): 372–8. doi :10.1080/02841860701644052 . PMID 17899454 . S2CID 45674826 . Robinson WE, Montefiori DC, Mitchell WM (1987). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses . 3 (3): 265–82. doi :10.1089/aid.1987.3.265 . PMID 2829950 . Montefiori DC, Robinson WE, Mitchell WM (1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1" . Proc. Natl. Acad. Sci. U.S.A . 85 (23): 9248–52. 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Anabolism Catabolism Transport M6P tagging
Activity Regulation Classification Kinetics Types
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