60S ribosomal protein L19

RPL19
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UG0, 4V6X, 5A2Q, 5AJ0, 4UJE, 4UJD, 4D67, 4V5Z, 4UJC, 4D5Y
Identifiers
Aliases	RPL19, L19, ribosomal protein L19
External IDs	OMIM: 180466; MGI: 98020; HomoloGene: 68105; GeneCards: RPL19; OMA:RPL19 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	39,204,840 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	97,921,318 bp
RNA expression pattern
	Top expressed in
	gonad; ; Achilles tendon; ; granulocyte; ; lymph node; ; skin of thigh; ; left ovary; ; skin of hip; ; canal of the cervix; ; right ovary; ; olfactory zone of nasal mucosa;
	Top expressed in
	epiblast; ; embryo; ; embryo; ; ventricular zone; ; thymus; ; urinary bladder; ; uterus; ; blastocyst; ; adrenal gland; ; ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome; protein binding; RNA binding; large ribosomal subunit rRNA binding; 5.8S rRNA binding;
Cellular component	cytosol; ribosome; membrane; focal adhesion; intracellular anatomical structure; cytosolic large ribosomal subunit; polysomal ribosome;
Biological process	protein biosynthesis; viral transcription; SRP-dependent cotranslational protein targeting to membrane; translational initiation; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; rRNA processing; cytoplasmic translation; liver regeneration;
	Sources:Amigo / QuickGO
Orthologs
	6143
	19921
	ENSG00000108298
	ENSMUSG00000017404
	P84098
	P84099
	NM_000981; NM_001330200
	NM_001159483; NM_009078
	NP_000972; NP_001317129
	NP_001152955; NP_033104
	Wikidata
View/Edit Human	View/Edit Mouse

Large ribosomal subunit protein eL19 is a protein that in humans is encoded by the RPL19 gene.^[5]^[6]

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L19E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

Pseudogenes

There are 21 pseudogenes: RPL19P1,^[8] RPL19P2,^[9] RPL19P3,^[10] RPL19P4,^[11] RPL19P5,^[12] RPL19P6,^[13] RPL19P7,^[14] RPL19P8,^[15] RPL19P9,^[16] RPL19P10,^[17] RPL19P11,^[18] RPL19P12,^[19] RPL19P13,^[20] RPL19P14,^[21] RPL19P15,^[22] RPL19P16,^[23] RPL19P17,^[24] RPL19P18,^[25] RPL19P19,^[26] RPL19P20,^[27] and RPL19P21.^[28]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108298 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017404 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Feo S, Davies B, Fried M (Jun 1992). "The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome". Genomics. 13 (1): 201–7. doi:10.1016/0888-7543(92)90221-D. PMID 1577483.
^ "RPL19 ribosomal protein L19 [ Homo sapiens (human) ]".
^ "Entrez Gene: RPL19 ribosomal protein L19".
^ "Symbol report for RPL19P1". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P2". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P3". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P4". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P5". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P6". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P7". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P8". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P9". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P10". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P11". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P12". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P13". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P14". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P15". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P16". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P17". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P18". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P19". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P20". HUGO Gene Nomenclature Committee (HGNC).
^ "Symbol report for RPL19P21". HUGO Gene Nomenclature Committee (HGNC).

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Kumabe T, Sohma Y, Yamamoto T (1992). "Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19". Nucleic Acids Res. 20 (10): 2598. doi:10.1093/nar/20.10.2598. PMC 312399. PMID 1598220.
Chan YL, Lin A, McNally J, et al. (1987). "The primary structure of rat ribosomal protein L19. A determination from the sequence of nucleotides in a cDNA and from the sequence of amino acids in the protein". J. Biol. Chem. 262 (3): 1111–5. doi:10.1016/S0021-9258(19)75757-3. PMID 3542997.
Davies B, Fried M (1995). "The L19 ribosomal protein gene (RPL19): gene organization, chromosomal mapping, and novel promoter region". Genomics. 25 (2): 372–80. doi:10.1016/0888-7543(95)80036-L. PMID 7789970.
Henry JL, Coggin DL, King CR (1993). "High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2". Cancer Res. 53 (6): 1403–8. PMID 8095182.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
Deprez PH, Sempoux C, De Saeger C, et al. (2002). "Expression of cholecystokinin in the duodenum of patients with coeliac disease: respective role of atrophy and lymphocytic infiltration". Clin. Sci. 103 (2): 171–7. doi:10.1042/CS20020033. PMID 12149109.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bee A, Ke Y, Forootan S, et al. (2006). "Ribosomal protein l19 is a prognostic marker for human prostate cancer". Clin. Cancer Res. 12 (7 Pt 1): 2061–5. doi:10.1158/1078-0432.CCR-05-2445. PMID 16609016. S2CID 7231453.
Lederer CW, Torrisi A, Pantelidou M, et al. (2007). "Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis". BMC Genomics. 8: 26. doi:10.1186/1471-2164-8-26. PMC 1796866. PMID 17244347.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108298 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017404 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1577483-5] Feo S, Davies B, Fried M (Jun 1992). "The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome". Genomics. 13 (1): 201–7. doi:10.1016/0888-7543(92)90221-D. PMID 1577483.

[6] "RPL19 ribosomal protein L19 [ Homo sapiens (human) ]".

[entrez-7] "Entrez Gene: RPL19 ribosomal protein L19".

[8] "Symbol report for RPL19P1". HUGO Gene Nomenclature Committee (HGNC).

[9] "Symbol report for RPL19P2". HUGO Gene Nomenclature Committee (HGNC).

[10] "Symbol report for RPL19P3". HUGO Gene Nomenclature Committee (HGNC).

[11] "Symbol report for RPL19P4". HUGO Gene Nomenclature Committee (HGNC).

[12] "Symbol report for RPL19P5". HUGO Gene Nomenclature Committee (HGNC).

[13] "Symbol report for RPL19P6". HUGO Gene Nomenclature Committee (HGNC).

[14] "Symbol report for RPL19P7". HUGO Gene Nomenclature Committee (HGNC).

[15] "Symbol report for RPL19P8". HUGO Gene Nomenclature Committee (HGNC).

[16] "Symbol report for RPL19P9". HUGO Gene Nomenclature Committee (HGNC).

[17] "Symbol report for RPL19P10". HUGO Gene Nomenclature Committee (HGNC).

[18] "Symbol report for RPL19P11". HUGO Gene Nomenclature Committee (HGNC).

[19] "Symbol report for RPL19P12". HUGO Gene Nomenclature Committee (HGNC).

[20] "Symbol report for RPL19P13". HUGO Gene Nomenclature Committee (HGNC).

[21] "Symbol report for RPL19P14". HUGO Gene Nomenclature Committee (HGNC).

[22] "Symbol report for RPL19P15". HUGO Gene Nomenclature Committee (HGNC).

[23] "Symbol report for RPL19P16". HUGO Gene Nomenclature Committee (HGNC).

[24] "Symbol report for RPL19P17". HUGO Gene Nomenclature Committee (HGNC).

[25] "Symbol report for RPL19P18". HUGO Gene Nomenclature Committee (HGNC).

[26] "Symbol report for RPL19P19". HUGO Gene Nomenclature Committee (HGNC).

[27] "Symbol report for RPL19P20". HUGO Gene Nomenclature Committee (HGNC).

[28] "Symbol report for RPL19P21". HUGO Gene Nomenclature Committee (HGNC).

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60S ribosomal protein L19

Pseudogenes

References

Further reading