RS-56812

RS-56812
Identifiers
	IUPAC name N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide;
CAS Number	143137-35-3;
PubChem CID	6604789;
CompTox Dashboard (EPA)	DTXSID80398179 ;
Chemical and physical data
Formula	C18H21N3O2
Molar mass	311.385 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c14ccccc4n(C)cc1C(=O)C(=O)NC2CN3CCC2CC3;
	(verify)

RS-56812 is a potent and selective partial agonist at the 5HT₃ receptor.^[1] It has been shown to improve performance on animal tests of memory. Its use in humans is not well documented. ^[2]

References

^ Van Hooft JA, Vijverberg HP (March 1997). "RS-056812-198: partial agonist on native and antagonist on cloned 5-HT3 receptors". European Journal of Pharmacology. 322 (2–3): 229–33. doi:10.1016/s0014-2999(96)00993-4. PMID 9098692.
^ Terry AV, Buccafusco JJ, Prendergast MA, Jackson WJ, Fontana DL, Wong EH, et al. (December 1996). "The 5-HT3 receptor antagonist, RS-56812, enhances delayed matching performance in monkeys". NeuroReport. 8 (1): 49–54. doi:10.1097/00001756-199612200-00011. PMID 9051751. S2CID 42903427.

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[1] Van Hooft JA, Vijverberg HP (March 1997). "RS-056812-198: partial agonist on native and antagonist on cloned 5-HT3 receptors". European Journal of Pharmacology. 322 (2–3): 229–33. doi:10.1016/s0014-2999(96)00993-4. PMID 9098692.

[2] Terry AV, Buccafusco JJ, Prendergast MA, Jackson WJ, Fontana DL, Wong EH, et al. (December 1996). "The 5-HT3 receptor antagonist, RS-56812, enhances delayed matching performance in monkeys". NeuroReport. 8 (1): 49–54. doi:10.1097/00001756-199612200-00011. PMID 9051751. S2CID 42903427.

[1]

[2]

Identifiers

IUPAC name N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide
CAS Number	143137-35-3
PubChem CID	6604789
CompTox Dashboard (EPA)	DTXSID80398179
Chemical and physical data
Formula	C₁₈H₂₁N₃O₂
Molar mass	311.385 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES c14ccccc4n(C)cc1C(=O)C(=O)NC2CN3CCC2CC3
(verify)