G-protein coupled receptor
Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin .[ 1] There are two different subtypes CCKA and CCKB which are ~50% homologous :[ 2] Various cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug proglumide .
Protein Gene Tissue distribution Preferred ligand Function Mechanism CCKA (CCK1 ) CCKAR primarily gastrointestinal tract , lesser amounts in the CNS sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility Gq [ 3] [ 4] CCKB (CCK2 ) CCKBR primarily CNS, lesser amounts in the gastrointestinal tract gastrin ≈ CCK (receptor does not discriminate between sulfated and nonsulfated peptides) regulation of nociception , anxiety , memory and hunger Gq /G11 [ 4]
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