Tachykinin receptor

There are three known mammalian tachykinin receptors termed NK₁, NK₂ and NK₃. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called G_q-coupled).

Inhibitors of NK-1, known as NK-1 receptor antagonists, can be used as antiemetic agents, such as the drug aprepitant.^[1]

The genes and receptor ligands are as follows:^[2]

(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)

• Substance P
• G protein coupled receptors

• "Tachykinin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• Tachykinin+Receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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