Monocarboxylate transporter 5

SLC16A4
Identifiers
Aliases	SLC16A4, MCT4, MCT5, solute carrier family 16 member 4
External IDs	OMIM: 603878; MGI: 2385183; HomoloGene: 74529; GeneCards: SLC16A4; OMA:SLC16A4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	110,391,082 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	107,219,431 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; kidney tubule; ; glomerulus; ; metanephric glomerulus; ; retinal pigment epithelium; ; corpus epididymis; ; placenta; ; caput epididymis; ; jejunal mucosa; ; human kidney;
	Top expressed in
	right kidney; ; human kidney; ; proximal tubule; ; calvaria; ; Epithelium of choroid plexus; ; spermatocyte; ; tail of embryo; ; ventricular zone; ; neural layer of retina; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	symporter activity; monocarboxylic acid transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	monocarboxylic acid transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	9122
	229699
	ENSG00000168679
	ENSMUSG00000027896
	O15374
	Q8R0M8
NM_001201546; NM_001201547; NM_001201548; NM_001201549; NM_004696;
	NM_001319220
	NM_146136; NM_001310705
NP_001188475; NP_001188476; NP_001188477; NP_001188478; NP_001306149;
	NP_004687
	NP_001297634; NP_666248
	Wikidata
View/Edit Human	View/Edit Mouse

Monocarboxylate transporter 5 is a protein that in humans is encoded by the SLC16A4 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168679 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027896 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Price NT, Jackson VN, Halestrap AP (January 1998). "Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past". The Biochemical Journal. 329 (2): 321–8. doi:10.1042/bj3290321. PMC 1219047. PMID 9425115.
^ "Entrez Gene: SLC16A4 solute carrier family 16, member 4 (monocarboxylic acid transporter 5)".

Halestrap AP, Price NT (October 1999). "The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation". The Biochemical Journal. 343 (2): 281–99. doi:10.1042/bj3430281. PMC 1220552. PMID 10510291.
Halestrap AP, Meredith D (February 2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond". Pflügers Archiv. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID 12739169. S2CID 15498611.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Pilegaard H, Terzis G, Halestrap A, Juel C (May 1999). "Distribution of the lactate/H+ transporter isoforms MCT1 and MCT4 in human skeletal muscle". The American Journal of Physiology. 276 (5 Pt 1): E843-8. doi:10.1152/ajpendo.1999.276.5.E843. PMID 10329977.
Manning Fox JE, Meredith D, Halestrap AP (December 2000). "Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle". The Journal of Physiology. 529 (2): 285–93. doi:10.1111/j.1469-7793.2000.00285.x. PMC 2270204. PMID 11101640.
Philp NJ, Wang D, Yoon H, Hjelmeland LM (April 2003). "Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells". Investigative Ophthalmology & Visual Science. 44 (4): 1716–21. doi:10.1167/iovs.02-0287. PMID 12657613.
Juel C, Holten MK, Dela F (April 2004). "Effects of strength training on muscle lactate release and MCT1 and MCT4 content in healthy and type 2 diabetic humans". The Journal of Physiology. 556 (Pt 1): 297–304. doi:10.1113/jphysiol.2003.058222. PMC 1664883. PMID 14724187.
Settle P, Mynett K, Speake P, Champion E, Doughty IM, Sibley CP, D'Souza SW, Glazier J (July 2004). "Polarized lactate transporter activity and expression in the syncytiotrophoblast of the term human placenta". Placenta. 25 (6): 496–504. doi:10.1016/j.placenta.2003.11.009. PMID 15135232.
Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP (July 2005). "Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)". The Journal of Biological Chemistry. 280 (29): 27213–21. doi:10.1074/jbc.M411950200. PMID 15917240.
Merezhinskaya N, Ogunwuyi SA, Fishbein WN (February 2006). "Expression of monocarboxylate transporter 4 in human platelets, leukocytes, and tissues assessed by antibodies raised against terminal versus pre-terminal peptides". Molecular Genetics and Metabolism. 87 (2): 152–61. doi:10.1016/j.ymgme.2005.09.029. PMID 16403666.
Bickham DC, Bentley DJ, Le Rossignol PF, Cameron-Smith D (April 2006). "The effects of short-term sprint training on MCT expression in moderately endurance-trained runners". European Journal of Applied Physiology. 96 (6): 636–43. doi:10.1007/s00421-005-0100-x. PMID 16408234. S2CID 10354316.
Ullah MS, Davies AJ, Halestrap AP (April 2006). "The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism". The Journal of Biological Chemistry. 281 (14): 9030–7. doi:10.1074/jbc.M511397200. PMID 16452478.
Bishop D, Edge J, Thomas C, Mercier J (February 2007). "High-intensity exercise acutely decreases the membrane content of MCT1 and MCT4 and buffer capacity in human skeletal muscle". Journal of Applied Physiology. 102 (2): 616–21. doi:10.1152/japplphysiol.00590.2006. PMID 17082373. S2CID 336956.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168679 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027896 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9425115-5] Price NT, Jackson VN, Halestrap AP (January 1998). "Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past". The Biochemical Journal. 329 (2): 321–8. doi:10.1042/bj3290321. PMC 1219047. PMID 9425115.

[entrez-6] "Entrez Gene: SLC16A4 solute carrier family 16, member 4 (monocarboxylic acid transporter 5)".

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[5]

[6]

Monocarboxylate transporter 5

See also

References

Further reading