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DeutschSLC26A6
Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene.[5][6][7] It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.[8]
This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined.[7]
Associated diseases
[edit]Diseases associated with SLC26A6 include sialolithiasis and urolithiasis.[9]
See also
[edit]References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000225697 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023259 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lohi H, Kujala M, Kerkelä E, Saarialho-Kere U, Kestilä M, Kere J (November 2000). "Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger". Genomics. 70 (1): 102–112. doi:10.1006/geno.2000.6355. PMID 11087667.
- ^ Waldegger S, Moschen I, Ramirez A, Smith RJ, Ayadi H, Lang F, Kubisch C (February 2001). "Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family". Genomics. 72 (1): 43–50. doi:10.1006/geno.2000.6445. PMID 11247665.
- ^ a b "Entrez Gene: SLC26A6 solute carrier family 26, member 6".
- ^ Wang Z, Wang T, Petrovic S, Tuo B, Riederer B, Barone S, et al. (April 2005). "Renal and intestinal transport defects in Slc26a6-null mice". American Journal of Physiology. Cell Physiology. 4. 288 (4): C957 – C965. doi:10.1152/ajpcell.00505.2004. PMID 15574486. S2CID 23214608.
- ^ "SLC26A6 Gene - GeneCards | S26A6 Protein | S26A6 Antibody". www.genecards.org. Retrieved 2021-05-06.
Further reading
[edit]- Markovich D (October 2001). "Physiological roles and regulation of mammalian sulfate transporters". Physiological Reviews. 81 (4): 1499–1533. doi:10.1152/physrev.2001.81.4.1499. PMID 11581495. S2CID 30942862.
- Ignatovich O, Tomlinson IM, Popov AV, Brüggemann M, Winter G (November 1999). "Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire". Journal of Molecular Biology. 294 (2): 457–465. doi:10.1006/jmbi.1999.3243. PMID 10610771.
- Xie Q, Welch R, Mercado A, Romero MF, Mount DB (October 2002). "Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1". American Journal of Physiology. Renal Physiology. 283 (4): F826 – F838. doi:10.1152/ajprenal.00079.2002. PMID 12217875.
- Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
]* Chernova MN, Jiang L, Friedman DJ, Darman RB, Lohi H, Kere J, et al. (March 2005). "Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity". The Journal of Biological Chemistry. 280 (9): 8564–8580. doi:10.1074/jbc.M411703200. PMID 15548529.
- Kujala M, Tienari J, Lohi H, Elomaa O, Sariola H, Lehtonen E, Kere J (2006). "SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney". Nephron. Experimental Nephrology. 101 (2): e50 – e58. doi:10.1159/000086345. PMID 15956810. S2CID 26671784.
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Shcheynikov N, Wang Y, Park M, Ko SB, Dorwart M, Naruse S, et al. (May 2006). "Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6". The Journal of General Physiology. 127 (5): 511–524. doi:10.1085/jgp.200509392. PMC 2151520. PMID 16606687.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Alper SL, Stewart AK, Chernova MN, et al. (2007). "Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides". Epithelial Anion Transport in Health and Disease: The Role of the SLC26 Transporters Family. Novartis Foundation Symposia. Vol. 273. pp. 107–19, discussion 119–25, 261–4. doi:10.1002/0470029579.ch8. ISBN 9780470016244. PMID 17120764.
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