SLC26A6

SLC26A6
Identifiers
Aliases	SLC26A6, solute carrier family 26 member 6
External IDs	OMIM: 610068; MGI: 2159728; HomoloGene: 99903; GeneCards: SLC26A6; OMA:SLC26A6 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	48,635,493 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	108,742,117 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; Descending thoracic aorta; ; popliteal artery; ; tibial arteries; ; ascending aorta; ; oocyte; ; rectum; ; stromal cell of endometrium; ; left coronary artery; ; body of stomach;
	Top expressed in
	duodenum; ; jejunum; ; ileum; ; primary oocyte; ; yolk sac; ; pancreas; ; muscle tissue; ; skeletal muscle tissue; ; quadriceps femoris muscle; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	PDZ domain binding; formate transmembrane transporter activity; chloride transmembrane transporter activity; anion transmembrane transporter activity; sulfate transmembrane transporter activity; secondary active sulfate transmembrane transporter activity; bicarbonate transmembrane transporter activity; formate efflux transmembrane transporter activity; oxalate transmembrane transporter activity; protein binding; efflux transmembrane transporter activity; antiporter activity; chloride channel activity; inorganic anion exchanger activity;
Cellular component	integral component of membrane; membrane; intracellular membrane-bounded organelle; vesicle membrane; plasma membrane; integral component of plasma membrane; chloride channel complex; brush border membrane; basolateral plasma membrane; apical plasma membrane; endoplasmic reticulum; sperm midpiece; cytoplasmic vesicle membrane; cytoplasmic vesicle; intracellular anatomical structure; vesicle;
Biological process	oxalic acid secretion; mannitol transport; oxalate transport; formate transport; intracellular pH elevation; sulfate transport; epithelial fluid transport; angiotensin-activated signaling pathway; regulation of membrane potential; regulation of intracellular pH; cellular response to fructose stimulus; ion transport; transepithelial chloride transport; protein kinase C signaling; anion transport; transepithelial transport; cellular response to interferon-gamma; sperm capacitation; intestinal absorption; chloride transport; positive regulation of dipeptide transmembrane transport; cellular response to cAMP; anion transmembrane transport; sulfate transmembrane transport; bicarbonate transport; transmembrane transport; chloride transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	65010
	171429
	ENSG00000225697
	ENSMUSG00000023259
	Q9BXS9
	Q8CIW6
NM_134426; NM_001040454; NM_001281732; NM_001281733; NM_022911;
	NM_134263
	NM_134420
NP_001035544; NP_001268661; NP_001268662; NP_075062; NP_599025;
	NP_602298; NP_001035544.1
	NP_599252; NP_001395316
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene.^[5]^[6]^[7] It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.^[8]

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined.^[7]

Associated diseases

Diseases associated with SLC26A6 include sialolithiasis and urolithiasis.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000225697 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023259 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lohi H; Kujala M; Kerkela E; Saarialho-Kere U; Kestila M; Kere J (Jan 2001). "Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger". Genomics. 70 (1): 102–12. doi:10.1006/geno.2000.6355. PMID 11087667.
^ Waldegger S; Moschen I; Ramirez A; Smith RJ; Ayadi H; Lang F; Kubisch C (Mar 2001). "Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family". Genomics. 72 (1): 43–50. doi:10.1006/geno.2000.6445. PMID 11247665.
^ ^a ^b "Entrez Gene: SLC26A6 solute carrier family 26, member 6".
^ Wang, Zhaohui; Tong Wang; Snezana Petrovic; Biguang Tuo; Brigitte Riederer; Sharon Barone; John N. Lorenz; Ursula Seidler; Peter S. Aronson; Manoocher Soleimani (April 2005). "Renal and intestinal transport defects in Slc26a6-null mice". American Journal of Physiology. Cell Physiology. 4. 288 (4): C957–C965. doi:10.1152/ajpcell.00505.2004. PMID 15574486. S2CID 23214608.
^ "SLC26A6 Gene - GeneCards | S26A6 Protein | S26A6 Antibody". www.genecards.org. Retrieved 2021-05-06.

Markovich D (2001). "Physiological roles and regulation of mammalian sulfate transporters". Physiol. Rev. 81 (4): 1499–533. doi:10.1152/physrev.2001.81.4.1499. PMID 11581495. S2CID 30942862.
Ignatovich O, Tomlinson IM, Popov AV, et al. (2000). "Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire". J. Mol. Biol. 294 (2): 457–65. doi:10.1006/jmbi.1999.3243. PMID 10610771.
Xie Q, Welch R, Mercado A, et al. (2002). "Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1". Am. J. Physiol. Renal Physiol. 283 (4): F826–38. doi:10.1152/ajprenal.00079.2002. PMID 12217875.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Chernova MN, Jiang L, Friedman DJ, et al. (2005). "Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity". J. Biol. Chem. 280 (9): 8564–80. doi:10.1074/jbc.M411703200. PMID 15548529.
Kujala M, Tienari J, Lohi H, et al. (2006). "SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney". Nephron Exp. Nephrol. 101 (2): e50–8. doi:10.1159/000086345. PMID 15956810. S2CID 26671784.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Shcheynikov N, Wang Y, Park M, et al. (2006). "Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6". J. Gen. Physiol. 127 (5): 511–24. doi:10.1085/jgp.200509392. PMC 2151520. PMID 16606687.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Alper SL, Stewart AK, Chernova MN, et al. (2007). "Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides". Epithelial Anion Transport in Health and Disease: The Role of the SLC26 Transporters Family. Novartis Foundation Symposia. Vol. 273. pp. 107–19, discussion 119–25, 261–4. doi:10.1002/0470029579.ch8. ISBN 9780470016244. PMID 17120764.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000225697 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023259 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11087667-5] Lohi H; Kujala M; Kerkela E; Saarialho-Kere U; Kestila M; Kere J (Jan 2001). "Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger". Genomics. 70 (1): 102–12. doi:10.1006/geno.2000.6355. PMID 11087667.

[pmid11247665-6] Waldegger S; Moschen I; Ramirez A; Smith RJ; Ayadi H; Lang F; Kubisch C (Mar 2001). "Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family". Genomics. 72 (1): 43–50. doi:10.1006/geno.2000.6445. PMID 11247665.

[entrez-7] "Entrez Gene: SLC26A6 solute carrier family 26, member 6".

[8] Wang, Zhaohui; Tong Wang; Snezana Petrovic; Biguang Tuo; Brigitte Riederer; Sharon Barone; John N. Lorenz; Ursula Seidler; Peter S. Aronson; Manoocher Soleimani (April 2005). "Renal and intestinal transport defects in Slc26a6-null mice". American Journal of Physiology. Cell Physiology. 4. 288 (4): C957–C965. doi:10.1152/ajpcell.00505.2004. PMID 15574486. S2CID 23214608.

[9] "SLC26A6 Gene - GeneCards | S26A6 Protein | S26A6 Antibody". www.genecards.org. Retrieved 2021-05-06.

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SLC26A6

Associated diseases

See also

References

Further reading