Common name for more than 1,000 species of flowering plants in the family Convolvulaceae
Morning glory flower, Ipomoea nil An unopened spiral bud of a morning glory flower, Ipomoea purpurea 'Blue Star', a cultivar of Ipomoea tricolor photographed in Haverhill, Massachusetts Morning glory flower (Ipomoea purpurea ) Morning glory (also written as morning-glory [ 1] ) is the common name for over 1,000 species of flowering plants in the family Convolvulaceae , whose current taxonomy and systematics are in flux. Morning glory species belong to many genera , some of which are:
As the name suggests, most morning glory flowers unfurl into full bloom in the early morning. The flowers usually start to fade a few hours before the corolla begins to display visible curling. They prefer full solar exposure throughout the day, and mesic soils. Some morning glories, such as Ipomoea muricata , Ipomoea alba , and Ipomoea macrorhiza , are night-blooming flowers.
Ipomoea purpurea in Loganville, Georgia Ipomoea nil , a species of morning glory, was first known in China for its medicinal uses, due to the laxative properties of its seeds.
Ancient Mesoamerican civilizations used the morning glory species Ipomoea alba to convert the latex from the Castilla elastica tree and also the guayule plant to produce bouncing rubber balls.[ 2] The sulfur in the morning glory's juice served to vulcanize the rubber, a process antedating Charles Goodyear 's discovery by at least 3,000 years.[ 3] Aztec priests in Mexico were also known to use the plant's hallucinogenic properties (see Rivea corymbosa ).
In some places, such as Australian bushland, some species of morning glories develop thick roots and tend to grow in dense thickets. They can quickly spread by way of long, creeping stems. By crowding out, blanketing, and smothering other plants, morning glory has turned into a serious invasive weed problem.[ 4]
In parts of the US, species such as Calystegia sepium (hedge bindweed), Ipomoea purpurea (common morning glory) and Ipomoea indica (blue morning glory) have shown to be invasive. In fact, as of 2021, most non-native species of Ipomoea are currently illegal to cultivate, possess, and sell in the U.S. state of Arizona , and before 4 January 2020, this ban applied to native species, too. This is because some species of Convolvulaceae (like Convolvulus arvensis and Ipomoea × leucantha ) have been known to cause problems in crops, especially in cotton fields.[ 5] [ 6] Ipomoea aquatica is a federal noxious weed, though some states, like Texas, have acknowledged its status as a vegetable and allow it to be grown.[ 7] [ 8]
In cultivation, most are treated as perennial plants in frost-free areas and as annual plants in colder climates, but some species tolerate winter cold. Some species are strictly annual (e.g. Ipomoea nil ), producing many seeds, and some perennial species (e.g. I. indica ) are propagated by cuttings. Some moonflowers , which flower at night, are also in the morning glory family.
Because of their fast growth, twining habit, attractive flowers, and tolerance for poor, dry soils, some morning glories are excellent vines for creating summer shade on building walls when trellised, thus keeping the building cooler and reducing heating and cooling costs.
Popular varieties in contemporary western cultivation include 'Sunspots' , 'Heavenly Blue' , moonflower, cypress vine , and cardinal climber . The cypress vine is a hybrid, with the cardinal climber as one parent.
Many morning glories self-seed in the garden. They have a hard seed coat, which delays germination until late spring. Germination may be improved by soaking in warm water.[ 9]
Morning glory has been a favorite flower in Japan for many a long century.[ 10] The cultivation started in the Nara period (8th century).[ 10] The big booms of the selective breeding of the morning glory happened in the Edo era (17-19th century).[ 10] The large-flowered morning glory was broadly cultivated as a hobby flower. The varied Japanese morning glory (変化朝顔 Henka-asagao or mutant morning glory) was created.[ 10] [ 11]
Stereo image Parallel view ( )
Cross-eye view ( )
Morning glory seeds, mixed colors
Ipomoea aquatica , known as water spinach, water morning glory, water convolvulus, ong-choy, kang-kung , or swamp cabbage, is popularly used as a green vegetable, especially in East and Southeast Asian cuisines . In the US, I. aquatica is a federal noxious weed , and can be illegal to grow, import, possess, or sell without a permit. A market exists, though, for the plant's powerful culinary potential.[ 8] As of 2005, the state of Texas has acknowledged that water spinach is a highly prized vegetable in many cultures, and has allowed it to be grown for personal consumption, in part because it is known to have been grown in Texas for more than 15 years and has not yet escaped cultivation.[ 7]
The genus Ipomoea also contains the sweet potato (I. batatas ). Though the term "morning glory" is not usually extended to I. batatas , sometimes it may be referred to as a "tuberous morning glory" in a horticultural context. Some cultivars of I. batatas are grown for their ornamental value, rather than for the edible tuber.
Chemistry and ethnobotany [ edit ] The seeds of many species of morning glory contain ergoline alkaloids such as the psychoactive and/or psychedelic lysergamides ergine (lysergic acid amide; LSA) and isoergine (isolysergic acid amide; iso-LSA), which are closely structurally related to lysergic acid diethylamide (LSD).[ 12] [ 13] [ 14] Seeds of Ipomoea tricolor and Turbina corymbosa (syn. R. corymbosa ) are used as psychedelics .[ 15] The seeds of morning glory can produce similar effects to LSD when ingested in sufficient numbers, often numbering into the hundreds. Though the chemicals ergine and isoergine are not legal in some countries, the seeds are found in many gardening stores; however, some claim the seeds from commercial sources can sometimes be coated in some kind of pesticide or methylmercury (although the latter is illegal in the UK and the US).[ 16] The onset is 20 to 180 minutes and the duration is 4 to 10 hours.[ 17] Previously thought to be exclusively synthetic compounds , methylergometrine and methysergide have also been reported to occur in Argyreia nervosa .[ 12] [ 18]
^ BSBI List 2007 (xls) . Botanical Society of Britain and Ireland . Archived from the original (xls) on 2015-06-26. Retrieved 2014-10-17 . ^ Hosler, Dorothy; Burkett, Sandra L.; Tarkanian, Michael J. (18 June 1999). "Prehistoric Polymers: Rubber Processing in Ancient Mesoamerica" . Science . 284 (5422): 1988– 1991. doi :10.1126/science.284.5422.1988 . PMID 10373117 . Archived from the original on 25 October 2021. Retrieved 25 October 2021 – via science.org (Atypon). ^ "Rubber processed in ancient Mesoamerica, MIT researchers find" . News.mit.edu . 14 July 1999. Archived from the original on 25 October 2021. Retrieved 25 October 2021 . ^ "Archived copy" (PDF) . Archived from the original (PDF) on 2017-03-29. Retrieved 2020-03-24 .{{cite web }}
: CS1 maint: archived copy as title (link ) ^ "Why We Can't Sell Native Morning Glories" . Desertsurvivors.org . Archived from the original on 2021-09-03. Retrieved 2021-09-03 . ^ "The Curious Case of Arizona's Morning Glories (Ipomoea spp.)" (PDF) . Archived (PDF) from the original on 2020-11-26. Retrieved 2021-09-03 . ^ a b "Texas Register - The Portal to Texas History" . The Portal to Texas History . Archived from the original on 2007-07-26. Retrieved 2018-08-17 . ^ a b "USDA weed factsheet" (PDF) . Aphis.usda.gov . Archived (PDF) from the original on 12 June 2012. Retrieved 25 October 2021 . ^ "How to Grow Morning Glories" . wikiHow . Archived from the original on 2021-10-03. Retrieved 2021-10-03 . ^ a b c d "The Japan Magazine A Representative Monthly of Things Japanese vol 7" S. Murayama, Japan magazine Company 1916, p175 ^ くらしの植物苑特別企画「伝統の朝顔」 Archived 2022-02-18 at the Wayback Machine National Museum of Japanese History. ^ a b Chen W, De Wit-Bos L (2020). Risk assessment of Argyreia nervosa (PDF) (Report). doi :10.21945/rivm-2019-0210 . ^ Shulgin AT (1976). "Psychotomimetic Agents". In Gordon M (ed.). Psychopharmacological Agents: Use, Misuse and Abuse . Medicinal Chemistry: A Series of Monographs. Vol. 4. Academic Press. p. 59–146. doi :10.1016/b978-0-12-290559-9.50011-9 . ISBN 978-0-12-290559-9 . ^ Brimblecombe RW, Pinder RM (1975). "Indolealkylamines and Related Compounds". Hallucinogenic Agents . Bristol: Wright-Scientechnica. pp. 98– 144. ISBN 978-0-85608-011-1 . OCLC 2176880 . OL 4850660M . ^ Vargas, Theresa (2006-05-03). "A '60s Buzz Recycled" . The Washington Post . Archived from the original on 2011-01-23. Retrieved 2010-05-13 . ^ Johnnson, Timothy (1999). CRC Ethnobotany Desk Reference . CRC Press. p. 431. ISBN 0-8493-1187-X . ^ Tittarelli R, Mannocchi G, Pantano F, Romolo FS (January 2015). "Recreational use, analysis and toxicity of tryptamines" . Curr Neuropharmacol . 13 (1): 26– 46. doi :10.2174/1570159X13666141210222409 . hdl :11573/874462 . PMID 26074742 . Ergine, or lysergic acid amide (LSA), is an alkaloid of the ergoline family closely related to LSD, found in the seeds of Argyreia nervosa (Hawaiian baby woodrose) and Ipomoea violacea (Morning Glories). Hallucinogenic activity of LSA occurs with 4-10 seeds of Argyreia nervosa or with 150–200 seeds (3–6 g) of Ipomoea violacea: seeds could be crushed or eaten whole, or also drunk as an extract, after soaking in water [42]. The onset of the hallucinatory effects, after ingestion of Hawaiian Baby Woodrose, is from 20 to 40 minutes and their total duration is from 5 to 8 hours: the plateau is reached after 4-6 hours and the return to normality is after 1-2 hours from the plateau. [...] However, as regards to the assumption of the Morning Glory seeds, the onset of the hallucinatory effects is from 30 to 180 minutes and they last for 4 to 10 hours. The users reported that they return to normality after about 24 hours [67]. ^ Paulke A, Kremer C, Wunder C, Wurglics M, Schubert-Zsilavecz M, Toennes SW (April 2015). "Studies on the alkaloid composition of the Hawaiian Baby Woodrose Argyreia nervosa, a common legal high". Forensic Sci Int . 249 : 281– 293. doi :10.1016/j.forsciint.2015.02.011 . PMID 25747328 . Everitt, J.H.; Lonard, R.L.; Little, C.R. (2007). Weeds in South Texas and Northern Mexico . Lubbock: Texas Tech University Press. ISBN 978-0-89672-614-7 . Furst, Peter (1990). Flesh of the Gods . ISBN 978-0-88133-477-7 . Schultes, Richard Evans (1976). Hallucinogenic Plants . Elmer W. Smith, illustrator. New York: Golden Press. ISBN 0-307-24362-1 .
No ring subs. 4-Hydroxytryptamines 5-Hydroxytryptamines 5-Methoxytryptamines Other ring subs. 2,N ,N -TMT 4,N ,N -TMT 5-Bromo-DMT 5-N ,N -TMT 7,N ,N -TMT 5-Fluoro-DMT 5-MeO-2,N ,N -TMT 5-MeO-4,N ,N -TMT 6-Fluoro-DMT Bretisilocin (GM-2505; 5-fluoro-MET) α-Alkyltryptamines Others Ergolines /lysergamides (e.g., LSD ) Harmala alkaloids and β-carbolines (e.g., harmine , harmaline ) Iboga alkaloids (e.g., 18-MAC , 18-MC , coronaridine , ibogaine , ibogamine , ME-18-MC , noribogaine , tabernanthine , voacangine ) Ibogalogs (e.g., ibogainalog ) Partial ergolines (e.g., NDTDI , RU-28306 , DEIMDHPCA , CT-5252 ) Piperidinylethylindoles (e.g., Pip-T ) Pyrrolidinylethylindoles (e.g., Pyr-T , 5-MeO-pyr-T ) Pyrrolidinylmethylindoles (e.g., MPMI , 4-HO-MPMI (lucigenol) , 5-MeO-MPMI )
Others: 2C-G-x (e.g., 2C-G-3 , 2C-G-5 ) β-Keto-2C-B (βk-2C-B) β-Keto-2C-I (βk-2C-I) β-Methyl-2C-B (BMB) (e.g., BOB , BOD , BOH-2C-B ) (e.g., HOT-2 , HOT-7 , HOT-17 ) N -Ethyl-2C-B (e.g., 2CD-2-ETO , 2CD-5-ETO , 2CE-5-ETO , 2CE-5iPrO , 2CT2-5-ETO ) Others 2-TOET 2-TOM 25B-NAcPip 4-HA 5-TOET 5-TOM Benzofurans (e.g., 5-APB , 5-APDB , 6-APB , 6-APDB , F-2 , F-22 ) Benzothiophenes (e.g., 5-APBT , 6-APBT ) DMAs (e.g., 2,4-DMA , 3,4-DMA ) Fenfluramine MMA (3-MeO-4-MA) Norfenfluramine (e.g., 25D-NM-NDEAOP , DOB-NDEPA , DOI-NDEPA , DOM-NDEPA , DOTFM-NDEPA , M-NDEPA , TMA-2-NDEPA ) PMA (4-MA) (e.g., TMA-3 , TMA-4 , TMA-5 , TMA-6 ) TOMSO ZDCM-04 1-Aminomethylindanes (e.g., 2CB-Ind , jimscaline ) 2-Aminoindanes (e.g., DOM-AI ) 2-Aminotetralins (e.g., DOM-AT ) 3-Phenylpiperidines (e.g., LPH-5 , LPH-48 ) Benzazepines (e.g., lorcaserin ) Benzocyclobutenes (e.g., 2CBCB-NBOMe , TCB-2 , tomscaline ) Benzoxepins (e.g., BBOX , IBOX , TFMBOX ) DMBMPP (juncosamine) Ergolines /lysergamides (e.g., LSD ) Glaucine IHCH-7113 Partial ergolines (e.g., NDTDI , DEIMDHPCA , DEMPDHPCA , DEMTMPDHPCA , DEMNDHPCA ) Phenylcyclopropylamines (e.g., DMCPA , TMT ) Phenylmorpholines (phenmetrazines) (e.g., 2C-B-morpholine ) Phenyloxazolamines (aminorexes ) (e.g., 2C-B-aminorex ) Z3517967757 ZC-B
Others Natural sources Tryptamines: Acacia spp. (e.g., Acacia acuminata , Acacia confusa ) Ayahuasca and vinho de Jurema (e.g., Psychotria viridis (chacruna) , Dipolopterys cabrerana (chaliponga, chacruna) , Mimosa tenuiflora (Mimosa hostilis ; jurema) ) Brosimum (e.g., Brosimum acutifolium (takini) ) Hallucinogenic snuffs (e.g., Anadenanthera peregrina (yopo, jopo, cohoba, parica, ebene) , Anadenanthera colubrina (vilca, cebil) ) Incilius alvarius (Bufo alvarius ; Colorado River toad, Sonoran Desert toad; bufo) Psilocybin-containing mushrooms (magic mushrooms, shrooms) (e.g., Psilocybe cubensis , Psilocybe mexicana (teonanacatl) )
5-HT1
5-HT1A
Agonists: 8-OH-DPAT Adatanserin Amphetamine Antidepressants (e.g., etoperidone , hydroxynefazodone , nefazodone , trazodone , triazoledione , vilazodone , vortioxetine ) Atypical antipsychotics (e.g., aripiprazole , asenapine , brexpiprazole , cariprazine , clozapine , lurasidone , quetiapine , ziprasidone ) Azapirones (e.g., buspirone , eptapirone , gepirone , perospirone , tandospirone ) Bay R 1531 Befiradol BMY-14802 Cannabidiol Dimemebfe Dopamine Ebalzotan Eltoprazine Enciprazine Ergolines (e.g., bromocriptine , cabergoline , dihydroergotamine , ergotamine , lisuride , LSD , methylergometrine (methylergonovine) , methysergide , pergolide ) F-11461 F-12826 F-13714 F-14679 F-15063 F-15599 Flesinoxan Flibanserin Flumexadol Hypidone Lesopitron LY-293284 LY-301317 mCPP MKC-242 Naluzotan NBUMP Osemozotan Oxaflozane Pardoprunox Piclozotan Rauwolscine Repinotan Roxindole RU-24969 S-14506 S-14671 S-15535 Sarizotan Serotonin (5-HT) SSR-181507 Sunepitron Tryptamines (e.g., 5-CT , 5-MeO-DMT , 5-MT , bufotenin , DMT , indorenate , N-Me-5-HT , psilocin , psilocybin ) TGBA01AD U-92016-A Urapidil Vilazodone Xaliproden Yohimbine Antagonists: Atypical antipsychotics (e.g., iloperidone , risperidone , sertindole ) AV965 Beta blockers (e.g., alprenolol , carteolol , cyanopindolol , iodocyanopindolol , isamoltane , oxprenolol , penbutolol , pindobind , pindolol , propranolol , tertatolol ) BMY-7378 CSP-2503 Dotarizine Ergolines (e.g., metergoline ) FCE-24379 Flopropione GR-46611 Isamoltane Lecozotan Mefway Metitepine (methiothepin) MIN-117 (WF-516) MPPF NAN-190 Robalzotan S-15535 SB-649915 SDZ 216-525 Spiperone Spiramide Spiroxatrine UH-301 WAY-100135 WAY-100635 Xylamidine
5-HT1B
Agonists: Anpirtoline CGS-12066A CP-93129 CP-94253 CP-122288 CP-135807 Eltoprazine Ergolines (e.g., bromocriptine , dihydroergotamine , ergotamine , methylergometrine (methylergonovine) , methysergide , pergolide ) mCPP RU-24969 Serotonin (5-HT) Triptans (e.g., avitriptan , donitriptan , eletriptan , sumatriptan , zolmitriptan ) TFMPP Tryptamines (e.g., 5-BT , 5-CT , 5-MT , DMT ) Vortioxetine
5-HT1D
Agonists: CP-122288 CP-135807 CP-286601 Ergolines (e.g., bromocriptine , cabergoline , dihydroergotamine , ergotamine , LSD , methysergide ) GR-46611 L-694247 L-772405 mCPP PNU-109291 PNU-142633 Serotonin (5-HT) TGBA01AD Triptans (e.g., almotriptan , avitriptan , donitriptan , eletriptan , frovatriptan , naratriptan , rizatriptan , sumatriptan , zolmitriptan ) Tryptamines (e.g., 5-BT , 5-CT , 5-Et-DMT , 5-MT , 5-(nonyloxy)tryptamine , DMT )
5-HT1E
5-HT1F
5-HT2
5-HT2A
Agonists: 25H/NB series (e.g., 25I-NBF , 25I-NBMD , 25I-NBOH , 25I-NBOMe , 25B-NBOMe , 25C-NBOMe , 25TFM-NBOMe , 2CBCB-NBOMe , 25CN-NBOH , 2CBFly-NBOMe ) 2Cs (e.g., 2C-B , 2C-E , 2C-I , 2C-T-2 , 2C-T-7 , 2C-T-21 ) 2C-B-FLY 2CB-Ind 5-Methoxytryptamines (5-MeO-DET , 5-MeO-DiPT , 5-MeO-DMT , 5-MeO-DPT , 5-MT ) α-Alkyltryptamines (e.g., 5-Cl-αMT , 5-Fl-αMT , 5-MeO-αET , 5-MeO-αMT , α-Me-5-HT , αET , αMT ) AL-34662 AL-37350A Bromo-DragonFLY Dimemebfe DMBMPP DOx (e.g., DOB , DOC , DOI , DOM ) Efavirenz Ergolines (e.g., 1P-LSD , ALD-52 , bromocriptine , cabergoline , ergine (LSA) , ergometrine (ergonovine) , ergotamine , lisuride , LA-SS-Az , LSB , LSD , LSD-Pip , LSH , LSP , methylergometrine (methylergonovine) , pergolide ) Flumexadol IHCH-7113 Jimscaline Lorcaserin MDxx (e.g., MDA (tenamfetamine) , MDMA (midomafetamine) , MDOH , MMDA ) O-4310 Oxaflozane PHA-57378 PNU-22394 PNU-181731 RH-34 SCHEMBL5334361 Phenethylamines (e.g., lophophine , mescaline ) Piperazines (e.g., BZP , quipazine , TFMPP ) Serotonin (5-HT) TCB-2 TFMFly Tryptamines (e.g., 5-BT , 5-CT , bufotenin , DET , DiPT , DMT , DPT , psilocin , psilocybin , tryptamine ) Antagonists: 5-I-R91150 5-MeO-NBpBrT AC-90179 Adatanserin Altanserin Antihistamines (e.g., cyproheptadine , hydroxyzine , ketotifen , perlapine ) AMDA Atypical antipsychotics (e.g., amperozide , aripiprazole , asenapine , blonanserin , brexpiprazole , carpipramine , clocapramine , clorotepine , clozapine , fluperlapine , gevotroline , iloperidone , lurasidone , melperone , mosapramine , ocaperidone , olanzapine , paliperidone , quetiapine , risperidone , sertindole , zicronapine , ziprasidone , zotepine ) Chlorprothixene Cinanserin CSP-2503 Deramciclane Dotarizine Eplivanserin Ergolines (e.g., amesergide , LY-53857 , LY-215840 , mesulergine , metergoline , methysergide , sergolexole ) Fananserin Flibanserin Glemanserin Irindalone Ketanserin KML-010 Landipirdine LY-393558 mCPP Medifoxamine Metitepine (methiothepin) MIN-117 (WF-516) Naftidrofuryl Nantenine Nelotanserin Opiranserin (VVZ-149) Pelanserin Phenoxybenzamine Pimavanserin Pirenperone Pizotifen Pruvanserin Rauwolscine Ritanserin Roluperidone S-14671 Sarpogrelate Serotonin antagonists and reuptake inhibitors (e.g., etoperidone , hydroxynefazodone , lubazodone , mepiprazole , nefazodone , triazoledione , trazodone ) SR-46349B TGBA01AD Teniloxazine Temanogrel Tetracyclic antidepressants (e.g., amoxapine , aptazapine , esmirtazapine , maprotiline , mianserin , mirtazapine ) Tricyclic antidepressants (e.g., amitriptyline ) Typical antipsychotics (e.g., chlorpromazine , fluphenazine , haloperidol , loxapine , perphenazine , pimozide , pipamperone , prochlorperazine , setoperone , spiperone , spiramide , thioridazine , thiothixene , trifluoperazine ) Volinanserin Xylamidine Yohimbine
5-HT2B
Agonists: 4-Methylaminorex Aminorex Amphetamines (e.g., chlorphentermine , cloforex , dexfenfluramine , fenfluramine , levofenfluramine , norfenfluramine ) BW-723C86 DOx (e.g., DOB , DOC , DOI , DOM ) Ergolines (e.g., cabergoline , dihydroergocryptine , dihydroergotamine , ergotamine , methylergometrine (methylergonovine) , methysergide , pergolide ) Lorcaserin MDxx (e.g., MDA (tenamfetamine) , MDMA (midomafetamine) , MDOH , MMDA ) Piperazines (e.g., TFMPP ) PNU-22394 Ro60-0175 Serotonin (5-HT) Tryptamines (e.g., 5-BT , 5-CT , 5-MT , α-Me-5-HT , bufotenin , DET , DiPT , DMT , DPT , psilocin , psilocybin , tryptamine ) Antagonists: Agomelatine Atypical antipsychotics (e.g., amisulpride , aripiprazole , asenapine , brexpiprazole , cariprazine , clozapine , N-desalkylquetiapine (norquetiapine) , N-desmethylclozapine (norclozapine) , olanzapine , pipamperone , quetiapine , risperidone , ziprasidone ) Cyproheptadine EGIS-7625 Ergolines (e.g., amesergide , bromocriptine , lisuride , LY-53857 , LY-272015 , mesulergine ) Ketanserin LY-393558 mCPP Metadoxine Metitepine (methiothepin) Pirenperone Pizotifen Propranolol PRX-08066 Rauwolscine Ritanserin RS-127445 Sarpogrelate SB-200646 SB-204741 SB-206553 SB-215505 SB-221284 SB-228357 SDZ SER-082 Tegaserod Tetracyclic antidepressants (e.g., amoxapine , mianserin , mirtazapine ) Trazodone Typical antipsychotics (e.g., chlorpromazine ) TIK-301 Yohimbine
5-HT2C
Agonists: 2Cs (e.g., 2C-B , 2C-E , 2C-I , 2C-T-2 , 2C-T-7 , 2C-T-21 ) 5-Methoxytryptamines (5-MeO-DET , 5-MeO-DiPT , 5-MeO-DMT , 5-MeO-DPT , 5-MT ) α-Alkyltryptamines (e.g., 5-Cl-αMT , 5-Fl-αMT , 5-MeO-αET , 5-MeO-αMT , α-Me-5-HT , αET , αMT ) A-372159 AL-38022A Alstonine CP-809101 Dimemebfe DOx (e.g., DOB , DOC , DOI , DOM ) Ergolines (e.g., ALD-52 , cabergoline , dihydroergotamine , ergine (LSA) , ergotamine , lisuride , LA-SS-Az , LSB , LSD , LSD-Pip , LSH , LSP , pergolide ) Flumexadol Lorcaserin MDxx (e.g., MDA (tenamfetamine) , MDMA (midomafetamine) , MDOH , MMDA ) MK-212 ORG-12962 ORG-37684 Oxaflozane PHA-57378 Phenethylamines (e.g., lophophine , mescaline ) Piperazines (e.g., aripiprazole , BZP , mCPP , quipazine , TFMPP ) PNU-22394 PNU-181731 Ro60-0175 Ro60-0213 Serotonin (5-HT) Tryptamines (e.g., 5-BT , 5-CT , bufotenin , DET , DiPT , DMT , DPT , psilocin , psilocybin , tryptamine ) Vabicaserin WAY-629 WAY-161503 YM-348 Antagonists: Adatanserin Agomelatine Atypical antipsychotics (e.g., asenapine , clorotepine , clozapine , fluperlapine , iloperidone , melperone , olanzapine , paliperidone , quetiapine , risperidone , sertindole , ziprasidone , zotepine ) Captodiame CEPC Cinanserin Cyproheptadine Deramciclane Desmetramadol Dotarizine Eltoprazine Ergolines (e.g., amesergide , bromocriptine , LY-53857 , LY-215840 , mesulergine , metergoline , methysergide , sergolexole ) Etoperidone Fluoxetine FR-260010 Irindalone Ketanserin Ketotifen Latrepirdine (dimebolin) Medifoxamine Metitepine (methiothepin) Nefazodone Pirenperone Pizotifen Propranolol Ritanserin RS-102221 S-14671 SB-200646 SB-206553 SB-221284 SB-228357 SB-242084 SB-243213 SDZ SER-082 Tedatioxetine Tetracyclic antidepressants (e.g., amoxapine , aptazapine , esmirtazapine , maprotiline , mianserin , mirtazapine ) TIK-301 Tramadol Trazodone Tricyclic antidepressants (e.g., amitriptyline , nortriptyline ) Typical antipsychotics (e.g., chlorpromazine , loxapine , pimozide , pipamperone , thioridazine ) Xylamidine
5-HT3 –7
5-HT3
Agonists: Alcohols (e.g., butanol , ethanol (alcohol) , trichloroethanol ) m-CPBG Phenylbiguanide Piperazines (e.g., BZP , mCPP , quipazine ) RS-56812 Serotonin (5-HT) SR-57227 SR-57227A Tryptamines (e.g., 2-Me-5-HT , 5-CT , bufotenidine (5-HTQ) ) Volatiles/gases (e.g., halothane , isoflurane , toluene , trichloroethane ) YM-31636 Antagonists: Alosetron Anpirtoline Arazasetron AS-8112 Atypical antipsychotics (e.g., clozapine , olanzapine , quetiapine ) Azasetron Batanopride Bemesetron (MDL-72222) Bupropion Cilansetron CSP-2503 Dazopride Dolasetron Galanolactone Granisetron Hydroxybupropion Lerisetron Memantine Ondansetron Palonosetron Ramosetron Renzapride Ricasetron Tedatioxetine Tetracyclic antidepressants (e.g., amoxapine , mianserin , mirtazapine ) Thujone Tropanserin Tropisetron Typical antipsychotics (e.g., loxapine ) Volatiles/gases (e.g., nitrous oxide , sevoflurane , xenon ) Vortioxetine Zacopride Zatosetron
5-HT4
5-HT5A
5-HT6
Agonists: Ergolines (e.g., dihydroergocryptine , dihydroergotamine , ergotamine , lisuride , LSD , mesulergine , metergoline , methysergide ) Hypidone Serotonin (5-HT) Tryptamines (e.g., 2-Me-5-HT , 5-BT , 5-CT , 5-MT , Bufotenin , E-6801 , E-6837 , EMD-386088 , EMDT , LY-586713 , N-Me-5-HT , ST-1936 , tryptamine ) WAY-181187 WAY-208466 Antagonists: ABT-354 Atypical antipsychotics (e.g., aripiprazole , asenapine , clorotepine , clozapine , fluperlapine , iloperidone , olanzapine , tiospirone ) AVN-101 AVN-211 AVN-322 AVN-397 BGC20-760 BVT-5182 BVT-74316 Cerlapirdine EGIS-12233 GW-742457 Idalopirdine Ketanserin Landipirdine Latrepirdine (dimebolin) Masupirdine Metitepine (methiothepin) MS-245 PRX-07034 Ritanserin Ro 04-6790 Ro 63-0563 SB-258585 SB-271046 SB-357134 SB-399885 SB-742457 Tetracyclic antidepressants (e.g., amoxapine , mianserin ) Tricyclic antidepressants (e.g., amitriptyline , clomipramine , doxepin , nortriptyline ) Typical antipsychotics (e.g., chlorpromazine , loxapine )
5-HT7
Antagonists: Atypical antipsychotics (e.g., amisulpride , aripiprazole , asenapine , brexpiprazole , clorotepine , clozapine , fluperlapine , olanzapine , risperidone , sertindole , tiospirone , ziprasidone , zotepine ) Butaclamol DR-4485 EGIS-12233 Ergolines (e.g., 2-Br-LSD (BOL-148) , amesergide , bromocriptine , cabergoline , dihydroergotamine , ergotamine , LY-53857 , LY-215840 , mesulergine , metergoline , methysergide , sergolexole ) JNJ-18038683 Ketanserin LY-215840 Metitepine (methiothepin) Ritanserin SB-258719 SB-258741 SB-269970 SB-656104 SB-656104A SB-691673 SLV-313 SLV-314 Spiperone SSR-181507 Tetracyclic antidepressants (e.g., amoxapine , maprotiline , mianserin , mirtazapine ) Tricyclic antidepressants (e.g., amitriptyline , clomipramine , imipramine ) Typical antipsychotics (e.g., acetophenazine , chlorpromazine , chlorprothixene , fluphenazine , loxapine , pimozide ) Vortioxetine