1cP-LSD

1cP-LSD
Clinical data
Other names	1cP, acid, LSD, Lucy
Dependence; liability	Low
Addiction; liability	None
Routes of; administration	By mouth, under the tongue
Legal status
Legal status	AU: S9 (Prohibited substance); BR: Class F2 (Prohibited psychotropics); CA: Unscheduled.; DE: NpSG (Industrial and scientific use only); UK: Under Psychoactive Substances Act;
Pharmacokinetic data
Onset of action	30 - 60 minutes
Duration of action	8 - 24 hours
Identifiers
	IUPAC name (6aR,9R)-N,N-diethyl-7-methyl-4-cyclopropylmethanoyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide;
CAS Number	2767597-50-0;
PubChem CID	155884675;
ChemSpider	107450612;
UNII	7UU7S6TN3J;
Chemical and physical data
Formula	C24H29N3O2
Molar mass	391.515 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN(CC)C(=O)[C@@H]5C=C2[C@@H](Cc3cn(C(=O)C1CC1)c4cccc2c34)N(C)C5;
	InChI InChI=1S/C24H29N3O2/c1-4-26(5-2)23(28)17-11-19-18-7-6-8-20-22(18)16(12-21(19)25(3)13-17)14-27(20)24(29)15-9-10-15/h6-8,11,14-15,17,21H,4-5,9-10,12-13H2,1-3H3/t17-,21-/m1/s1; Key:RAFUPYYDHPFASC-DYESRHJHSA-N;

1cP-LSD (N1-(cyclopropylmethanoyl)-lysergic acid diethylamide) is an acylated derivative of lysergic acid diethylamide (LSD), which has been sold as a designer drug. ^[1]^[2] It was first synthesized as a legal-LSD alternative by Lizard Labs, a Netherlands based research chemical laboratory.^[3] In tests on mice it was found to be an active psychedelic with similar potency to 1P-LSD.^[4]

Legal status

Sweden's public health agency suggested classifying 1cP-LSD as a dangerous substance on 18 December 2019 and later classified it as such on 22 April 2021.^[5]^[6]

References

^ Tanaka R, Kawamura M, Hakamatsuka T, Kikura-Hanajiri R (2020). "[Identification of LSD Derivatives, 1cP-LSD, MIPLA and 1B-LSD in Illegal Products as Paper Sheet]". Yakugaku Zasshi. 140 (11): 1405–1413. doi:10.1248/yakushi.20-00124. PMID 33132277.
^ Vincenti F, Gregori A, Flammini M, Di Rosa F, Salomone A (July 2021). "Seizures of New Psychoactive Substances on the Italian territory during the COVID-19 pandemic". Forensic Science International. 326: 110904. doi:10.1016/j.forsciint.2021.110904. PMC 8411784. PMID 34371393.
^ spotlight (2018-07-25). "About Us - Lizard Labs". lizardlabs.nl. Retrieved 2024-09-13.
^ Brandt SD, Kavanagh PV, Westphal F, Stratford A, Odland AU, Klein AK, et al. (June 2020). "Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1-cyclopropanoyl-d-lysergic acid diethylamide (1CP-LSD)". Drug Testing and Analysis. 12 (6): 812–826. doi:10.1002/dta.2789. PMC 9191646. PMID 32180350.
^ "Förordning (1999:58) om förbud mot vissa hälsofarliga varor".
^ "Tjugotre ämnen föreslås klassas som narkotika eller hälsofarlig vara" [Twenty-three substances are proposed to be classified as drugs or dangerous goods] (in Swedish). Folkhälsomyndigheten. December 18, 2019. Archived from the original on November 24, 2022. Retrieved May 28, 2020.

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[1] Tanaka R, Kawamura M, Hakamatsuka T, Kikura-Hanajiri R (2020). "[Identification of LSD Derivatives, 1cP-LSD, MIPLA and 1B-LSD in Illegal Products as Paper Sheet]". Yakugaku Zasshi. 140 (11): 1405–1413. doi:10.1248/yakushi.20-00124. PMID 33132277.

[pmid34371393-2] Vincenti F, Gregori A, Flammini M, Di Rosa F, Salomone A (July 2021). "Seizures of New Psychoactive Substances on the Italian territory during the COVID-19 pandemic". Forensic Science International. 326: 110904. doi:10.1016/j.forsciint.2021.110904. PMC 8411784. PMID 34371393.

[3] spotlight (2018-07-25). "About Us - Lizard Labs". lizardlabs.nl. Retrieved 2024-09-13.

[4] Brandt SD, Kavanagh PV, Westphal F, Stratford A, Odland AU, Klein AK, et al. (June 2020). "Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1-cyclopropanoyl-d-lysergic acid diethylamide (1CP-LSD)". Drug Testing and Analysis. 12 (6): 812–826. doi:10.1002/dta.2789. PMC 9191646. PMID 32180350.

[5] "Förordning (1999:58) om förbud mot vissa hälsofarliga varor".

[6] "Tjugotre ämnen föreslås klassas som narkotika eller hälsofarlig vara" [Twenty-three substances are proposed to be classified as drugs or dangerous goods] (in Swedish). Folkhälsomyndigheten. December 18, 2019. Archived from the original on November 24, 2022. Retrieved May 28, 2020.

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v t e Ergolines
Lysergic acid derivatives	2-Bromo-LSD (BOL-148) Amesergide Bromerguride (2-bromolisuride) Bromocriptine Cabergoline Dihydroergocornine Dihydroergocristine Dihydroergocryptine Dihydroergometrine (Dihydroergonovine, Dihydroergobasine) Dihydroergosine Dihydroergotamine Epicriptine Ergine (LSA; LA-111; Lysergamide) Ergocornine Ergocristine Ergocryptine Ergoloid (Dihydroergotoxine) Ergometrine (Ergonovine, Ergobasine) Ergometrinine Ergostine Ergotamine Ergotoxine Ergovaline Fludihydroergotamine Lisuride LY-215,840 LSH Lysergic acid Lysergic acid methyl ester Lysergine Lysergol Mergocriptine Mesulergine Metergoline Metergotamine MIPLA Methysergide Propisergide Sergolexole
Psychedelic lysergamides	1B-LSD 1cP-LSD 1P-ETH-LAD 1P-LSD AL-LAD ALD-52 BU-LAD CYP-LAD Diallyllysergamide (DAL) Dimethyllysergamide (DAM-57) ECPLA Ergonovine ETFELA ETH-LAD IP-LAD LAMPA LAE-32 LSD (lysergide) LPD-824 LSM-775 LSH LSD-Pip Lysergic Acid 2-Butylamide Lysergic Acid 2,4-Dimethylazetidide Lysergic Acid 3-Pentylamide Lysergic acid cyclobutylamide Lysergic acid cyclopentylamide Methylergometrine (Methylergonovine, Methylergobasine) MIPLA MLD-41 PARGY-LAD PRO-LAD
Clavines	9-Deacetoxyfumigaclavine C Agroclavine Chanoclavine Chanoclavine II Costaclavin Cycloclavine Elymoclavine Epoxyagroclavine Festuclavine Fumigaclavine A Fumigaclavine B Fumigaclavine C Paliclavine Penniclavine Setoclavine
Other ergolines	Acetergamine Brazergoline Cianergoline CY-208,243 Delergotrile Disulergine Dosergoside Ergoline Etisulergine Lergotrile Nicergoline Pergolide Proterguride Romergoline Terguride Tiomergine Voxergolide
Related compounds	Adrogolide Naxagolide Quinagolide
Natural sources	Achnatherum robustum (Sleepy Grass) Claviceps spp. (Ergot) Morning glory: Argyreia nervosa (Hawaiian Baby Woodrose), Ipomoea spp.(Morning Glory, Tlitliltzin, Badoh Negro), Rivea corymbosa (Coaxihuitl, Ololiúqui)

Clinical data

Other names	1cP, acid, LSD, Lucy
Dependence liability	Low
Addiction liability	None
Routes of administration	By mouth, under the tongue
Legal status
Legal status	AU: S9 (Prohibited substance) BR: Class F2 (Prohibited psychotropics) CA: Unscheduled. DE: NpSG (Industrial and scientific use only) UK: Under Psychoactive Substances Act
Pharmacokinetic data
Onset of action	30 - 60 minutes
Duration of action	8 - 24 hours
Identifiers
IUPAC name (6aR,9R)-N,N-diethyl-7-methyl-4-cyclopropylmethanoyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
CAS Number	2767597-50-0
PubChem CID	155884675
ChemSpider	107450612
UNII	7UU7S6TN3J
Chemical and physical data
Formula	C₂₄H₂₉N₃O₂
Molar mass	391.515 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCN(CC)C(=O)[C@@H]5C=C2[C@@H](Cc3cn(C(=O)C1CC1)c4cccc2c34)N(C)C5
InChI InChI=1S/C24H29N3O2/c1-4-26(5-2)23(28)17-11-19-18-7-6-8-20-22(18)16(12-21(19)25(3)13-17)14-27(20)24(29)15-9-10-15/h6-8,11,14-15,17,21H,4-5,9-10,12-13H2,1-3H3/t17-,21-/m1/s1 Key:RAFUPYYDHPFASC-DYESRHJHSA-N

1cP-LSD

Legal status

See also

References