TAAR8

TAAR8
Identifiers
Aliases	TAAR8, GPR102, TA5, TAR5, TRAR5, TaR-5, TaR-8, trace amine associated receptor 8
External IDs	OMIM: 606927; MGI: 2685995; HomoloGene: 77586; GeneCards: TAAR8; OMA:TAAR8 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	132,553,721 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	23,968,192 bp
RNA expression pattern
	Top expressed in
	pancreas; ; female reproductive system; ; organ system; ; material anatomical entity; ; kidney; ; renal cortex; ; vagina; ; islet of Langerhans; ; tibial nerve;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	trace-amine receptor activity; G protein-coupled receptor activity; signal transducer activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	83551
	382348
	ENSG00000146385
	ENSMUSG00000100186
	Q969N4
	Q5QD06
	NM_053278
	NM_001010837
	NP_444508
	NP_001010837
	Wikidata
View/Edit Human	View/Edit Mouse

Trace amine-associated receptor 8 is a protein that in humans is encoded by the TAAR8 gene.^[5]^[6]^[7] In humans, TAAR8 is the only trace amine-associated receptor that is known to be G_i/o-coupled.^[8]

In humans, molecular modelling and docking experiments have shown that putrescine fits into the binding pocket of the human TAAR6 and TAAR8 receptors.^[9]

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins, supplied by OMIM^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000146385 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000100186 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, et al. (September 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID 11574155.
^ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
^ ^a ^b "Entrez Gene: TAAR8 trace amine associated receptor 8".
^ Mühlhaus J, Dinter J, Nürnberg D, Rehders M, Depke M, Golchert J, et al. (November 2014). "Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile". International Journal of Molecular Sciences. 15 (11): 20638–55. doi:10.3390/ijms151120638. PMC 4264187. PMID 25391046.
^ Izquierdo C, Gómez-Tamayo JC, Nebel JC, Pardo L, Gonzalez A (January 2018). "Identifying human diamine sensors for death related putrescine and cadaverine molecules". PLOS Computational Biology. 14 (1): e1005945. Bibcode:2018PLSCB..14E5945I. doi:10.1371/journal.pcbi.1005945. PMC 5783396. PMID 29324768.

TAAR8

See also

References

Further reading