French
DeutschE2F4 - ويكيبيديا
E2F4 (E2F transcription factor 4) هوَ بروتين يُشَفر بواسطة جين E2F4 في الإنسان.[1][2]
الوظيفة
[عدل]![[أيقونة]](%D9%85%D9%84%D9%81:Crystal_xedit.svg){kind=small} | هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
الأهمية السريرية
[عدل] | هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
المراجع
[عدل]- ^ Ginsberg D، Vairo G، Chittenden T، Xiao ZX، Xu G، Wydner KL، DeCaprio JA، Lawrence JB، Livingston DM (ديسمبر 1994). "E2F-4, a new member of the E2F transcription factor family, interacts with p107". Genes Dev. ج. 8 ع. 22: 2665–79. DOI:10.1101/gad.8.22.2665. PMID:7958924.
- ^ Sardet C، Vidal M، Cobrinik D، Geng Y، Onufryk C، Chen A، Weinberg RA (أبريل 1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle". Proc Natl Acad Sci U S A. ج. 92 ع. 6: 2403–7. DOI:10.1073/pnas.92.6.2403. PMC:42492. PMID:7892279.
قراءة متعمقة
[عدل]- Bandyopadhyay D، Timchenko N، Suwa T، وآخرون (2001). "The human melanocyte: a model system to study the complexity of cellular aging and transformation in non-fibroblastic cells". Exp. Gerontol. ج. 36 ع. 8: 1265–75. DOI:10.1016/S0531-5565(01)00098-5. PMID:11602203.
- Beijersbergen RL، Kerkhoven RM، Zhu L، وآخرون (1994). "E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo". Genes Dev. ج. 8 ع. 22: 2680–90. DOI:10.1101/gad.8.22.2680. PMID:7958925.
- Xiao ZX، Ginsberg D، Ewen M، Livingston DM (1996). "Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases". Proc. Natl. Acad. Sci. U.S.A. ج. 93 ع. 10: 4633–7. DOI:10.1073/pnas.93.10.4633. PMC:39330. PMID:8643455.
- Moberg K، Starz MA، Lees JA (1996). "E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry". Mol. Cell. Biol. ج. 16 ع. 4: 1436–49. PMC:231128. PMID:8657117.
- Vidal M، Brachmann RK، Fattaey A، وآخرون (1996). "Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions". Proc. Natl. Acad. Sci. U.S.A. ج. 93 ع. 19: 10315–20. DOI:10.1073/pnas.93.19.10315. PMC:38381. PMID:8816797.
- Williams CD، Linch DC، Sørensen TS، وآخرون (1997). "The predominant E2F complex in human primary haemopoietic cells and in AML blasts contains E2F-4, DP-1 and p130". Br. J. Haematol. ج. 96 ع. 4: 688–96. DOI:10.1046/j.1365-2141.1997.d01-2086.x. PMID:9074408.
- Lindeman GJ، Gaubatz S، Livingston DM، Ginsberg D (1997). "The subcellular localization of E2F-4 is cell-cycle dependent". Proc. Natl. Acad. Sci. U.S.A. ج. 94 ع. 10: 5095–100. DOI:10.1073/pnas.94.10.5095. PMC:24637. PMID:9144196.
- Wang H، Shao N، Ding QM، وآخرون (1997). "BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases". Oncogene. ج. 15 ع. 2: 143–57. DOI:10.1038/sj.onc.1201252. PMID:9244350.
- Müller H، Moroni MC، Vigo E، وآخرون (1997). "Induction of S-phase entry by E2F transcription factors depends on their nuclear localization". Mol. Cell. Biol. ج. 17 ع. 9: 5508–20. PMC:232399. PMID:9271426.
- Pierce AM، Schneider-Broussard R، Philhower JL، Johnson DG (1998). "Differential activities of E2F family members: unique functions in regulating transcription". Mol. Carcinog. ج. 22 ع. 3: 190–8. DOI:10.1002/(SICI)1098-2744(199807)22:3<190::AID-MC7>3.0.CO;2-P. PMID:9688145.
- Ferreira R، Magnaghi-Jaulin L، Robin P، وآخرون (1998). "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase". Proc. Natl. Acad. Sci. U.S.A. ج. 95 ع. 18: 10493–8. DOI:10.1073/pnas.95.18.10493. PMC:27922. PMID:9724731.
- Timchenko NA، Wilde M، Darlington GJ (1999). "C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice". Mol. Cell. Biol. ج. 19 ع. 4: 2936–45. PMC:84088. PMID:10082561.
- Zheng N، Fraenkel E، Pabo CO، Pavletich NP (1999). "Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP". Genes Dev. ج. 13 ع. 6: 666–74. DOI:10.1101/gad.13.6.666. PMC:316551. PMID:10090723.
- Furukawa Y، Iwase S، Kikuchi J، وآخرون (1999). "Transcriptional repression of the E2F-1 gene by interferon-alpha is mediated through induction of E2F-4/pRB and E2F-4/p130 complexes". Oncogene. ج. 18 ع. 11: 2003–14. DOI:10.1038/sj.onc.1202500. PMID:10208422.
- Lam EW، Glassford J، van der Sman J، وآخرون (1999). "Modulation of E2F activity in primary mouse B cells following stimulation via surface IgM and CD40 receptors". Eur. J. Immunol. ج. 29 ع. 10: 3380–9. DOI:10.1002/(SICI)1521-4141(199910)29:10<3380::AID-IMMU3380>3.0.CO;2-C. PMID:10540350.
- Zhong X، Hemmi H، Koike J، وآخرون (2000). "Various AGC repeat numbers in the coding region of the human transcription factor gene E2F-4". Hum. Mutat. ج. 15 ع. 3: 296–7. DOI:10.1002/(SICI)1098-1004(200003)15:3<296::AID-HUMU18>3.0.CO;2-X. PMID:10679953.
- Takahashi Y، Rayman JB، Dynlacht BD (2000). "Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression". Genes Dev. ج. 14 ع. 7: 804–16. DOI:10.1101/gad.14.7.804. PMC:316494. PMID:10766737.
- Schwemmle S، Pfeifer GP (2000). "Genomic structure and mutation screening of the E2F4 gene in human tumors". Int. J. Cancer. ج. 86 ع. 5: 672–7. DOI:10.1002/(SICI)1097-0215(20000601)86:5<672::AID-IJC11>3.0.CO;2-X. PMID:10797289.
